产品名称

英文名称：AG-1478 (Tyrphostin AG-1478)

同义词

153436-53-4、AG-1478、N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine、Tyrphostin AG 1478、175178-82-2、Tyrphostin AG-1478、4-(3-Chloroanilino)-6,7-dimethoxyquinazoline、AG1478、AG 1478、4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-、AG-1478 (Tyrphostin A、酪氨酸激酶抑制剂AG 1478

产品性质

CAS编号：153436-53-4

分子式：C16H14ClN3O2

分子量：315.75

MDL号：MFCD00270914

PubChem编号：2051

别名：酪氨酸激酶抑制剂AG 1478

英文别名：153436-53-4|AG-1478|N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine|Tyrphostin AG 1478|175178-82-2|Tyrphostin AG-1478|4-(3-Chloroanilino)-6,7-dimethoxyquinazoline|AG1478|AG 1478|4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-|AG-1478 (Tyrphostin A

规格或纯度：≥98%

英文名称：AG-1478 (Tyrphostin AG-1478)

生化机理：AG1478 inhibited EGFR phosphorylation in CNE2 cells without reduced expression of EGFR protein. The activation of Akt and MAPK which are downstream molecules of EGFR signaling pathway, were also inhibited by AG1478 . Althoμgh AG 1478 inhibited cell growth, DNA synthesis, EGFR tyrosine kinase activity, and receptor autophosphorylation of each cell line in a dose-dependent manner, it was significantly more potent in U87MG. delta EGFR cells than in the other two cell lines . in vivo At the lowest dose, plasma drμg levels after the cessation of infusion declined with a half-life of approximately 43 min. EGFR activity, measured both by autophosphorylation and downstream signalling, was inhibited in a dose-dependent manner by injection of AG1478 in mice bearing xenografts of the human glioblastoma cell line U87MG

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg、10mg卖完停产，不再备货

产品介绍：AG-1478 (NSC 693255)是高效EGFR选择性抑制剂，IC50为3 nM，对HER2-Neu，PDGFR，Trk，Bcr-Abl和InsR无活性。AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.

IUPAC Name：N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

INCHI：InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

InChi Key：GFNNBHLJANVSQV-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC

Isomeric SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC

PubChem CID：2051

溶解性：25°C DMSO 25 mg/mL; Water <1 mg/mL; Ethanol 13 mg/mL

密度：1.337

敏感性：对热敏感

熔点：247 °C(dec.)

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装