产品名称

英文名称：Iloperidone

同义词

1-[4-[3-[4-(6-fluoro-1,2- benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3- methoxyphenyl]ethanone、Terasin、1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone、FT-0631148、J-503185、MFCD00866688、SMR002529575、Z1521553906、ILOPE、伊潘立酮

产品性质

CAS编号：133454-47-4

分子式：C24H27FN2O4

分子量：426.48

MDL号：MFCD00866688

PubChem编号：71360

别名：伊潘立酮

英文别名：1-[4-[3-[4-(6-fluoro-1,2- benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3- methoxyphenyl]ethanone|Terasin|1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone|FT-0631148|J-503185|MFCD00866688|SMR002529575|Z1521553906|ILOPE

规格或纯度：≥98%

英文名称：Iloperidone

生化机理：Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drμg’s efficacy on mood and cognition.

应用：A dopamine (D2) and serotonin (5HT2) receptor antagonist

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：250mg卖完停产，不再备货

产品介绍：Iloperidone (伊潘立酮; HP 873) 是D2/5-HT2受体拮抗剂，可作用于精神分裂症。A dopamine (D2) and serotonin (5HT2) receptor antagonistIloperidone is a dopamine (D2)/serotonin (5-HT2) receptor antagonist, used for the treatment of schizophrenia.A dopamine (D2) and serotonin (5HT2) receptor antagonist

ALogP：4.1

IUPAC Name：1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone

INCHI：InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3

InChi Key：XMXHEBAFVSFQEX-UHFFFAOYSA-N

Canonical SMILES：CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC

Isomeric SMILES：CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC

WGK Germany：1

RTECS：KM5777850

PubChem CID：71360

Reaxy-Rn：7233425

ChEBI：CHEBI65173

Wikipedia：Iloperidone

ChEMBL Ligand：CHEMBL14376

BindingDB Ligand：50034043

CAS Registry No.：133454-47-4

DrugBank Ligand：DB04946

DrugCentral Ligand：3294

GPCRdb Ligand：iloperidone

溶解性：DMSO 27 mg/mL Water <1 mg/mL Ethanol 4 mg/mL

敏感性：对热敏感

闪点(℉)：48.2°F

闪点(℃)：48.2°F

熔点：118-120°C

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

Merck Index：4900

产品包装