产品名称

英文名称：Tacrolimus Monohydrate

同义词

TACROLIMUS MONOHYDRATE、Tacrolimus hydrate、109581-93-3、Prograf、Protopic、Tsukubaenolide hydrate、FK-506 monohydrate、LCP-Tacro、Tacrolimus (monohydrate)、WM0HAQ4WNM、FK 506、Tacrolimus [USAN]、FR900506、FR 900506、UNII-WM0HAQ4WNM、Prograf (TN)、(1R,9S,12S,13R,14S,17R,、FK-506一水合物、FK-506 一水合物、他克莫司 一水合物、藤霉素一水合物

产品性质

CAS编号：109581-93-3

分子式：C44H69NO12 · H2O

分子量：822.03

MDL号：MFCD11045918

PubChem编号：5282315

别名：FK-506一水合物|FK-506 一水合物|他克莫司 一水合物|藤霉素一水合物

英文别名：TACROLIMUS MONOHYDRATE|Tacrolimus hydrate|109581-93-3|Prograf|Protopic|Tsukubaenolide hydrate|FK-506 monohydrate|LCP-Tacro|Tacrolimus (monohydrate)|WM0HAQ4WNM|FK 506|Tacrolimus [USAN]|FR900506|FR 900506|UNII-WM0HAQ4WNM|Prograf (TN)|(1R,9S,12S,13R,14S,17R,

规格或纯度：≥80.0%(HPLC)

英文名称：Tacrolimus Monohydrate

生化机理：It is a potent immunosuppressant, neuroprotective and neuroregenerative, and in vitro T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：产品介绍Tacrolimus monohydrate (FK506 monohydrate) 是大环内酯类化合物，Tacrolimus monohydrate 与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶 (calcineurin phosphatase)，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。ApplicationFK-506 monohydrate has been usedas an immunosuppressive agent in coculture medium to study the effect of immunologic reactionas a calcineurin inhibitor, in anhydrous Me2SO solutionto treat retinal pigment epithelial cells to measure possible cytotoxicity

IUPAC Name：(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone;hydrate

INCHI：InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1

InChi Key：NWJQLQGQZSIBAF-MLAUYUEBSA-N

Canonical SMILES：CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC.O

Isomeric SMILES：C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC.O

WGK Germany：3

RTECS：KD4201200

PubChem CID：5282315

Reaxy-Rn：6265275

溶解性：Soluble in 20 mg/mL of DMSO

敏感性：对光线和热敏感

熔点：127 °C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

Merck Index：9025

产品包装