产品名称

英文名称：AG-490 (Tyrphostin B42)

同义词

133550-30-8、AG-490、Tyrphostin B42、AG 490、Tyrphostin AG 490、(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide、AG490、Tyrphostin AG490、N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide、134036-52-5、(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enam、酪氨酸激酶抑制剂AG 490

产品性质

CAS编号：133550-30-8

分子式：C17H14N2O3

分子量：294.3

MDL号：MFCD00236452

PubChem编号：5328779

别名：酪氨酸激酶抑制剂AG 490

英文别名：133550-30-8|AG-490|Tyrphostin B42|AG 490|Tyrphostin AG 490|(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide|AG490|Tyrphostin AG490|N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide|134036-52-5|(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enam

规格或纯度：≥98%

英文名称：AG-490 (Tyrphostin B42)

生化机理：AG-490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.JAK2/3 inhibitor (IC 50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo .

应用：Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AG-490 (Tyrphostin AG 490)是EGFR抑制剂，IC50为100nM，比对ErbB2的抑制性高135倍，对Lck，Lyn，Btk，Syk和Src无活性。Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cellsAG-490 (Tyrphostin AG 490) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells

PubChem SID：488195367

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195367

IUPAC Name：(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

INCHI：InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+

InChi Key：TUCIOBMMDDOEMM-RIYZIHGNSA-N

Canonical SMILES：C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N

Isomeric SMILES：C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

WGK Germany：3

PubChem CID：5328779

CAS Registry No.：133550-30-8

ChEMBL Ligand：CHEMBL56543

溶解性：DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL

敏感性：对光敏感、对空气敏感、对热敏感

熔点：215°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH400 Very toxic to aquatic life

预防措施声明：P273,P321,P405,P501,P264,P270,P391,P330,P301+P316

产品包装