产品名称

英文名称：10058-F4

同义词

10058-F4、403811-55-2、5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone、5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one、(5E)-5-(4-ethylbenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one、10058F4、(E)-5-(4-Ethylbenzylidene)-2-mercaptothiazol-4(5H)-one、10058-

产品性质

CAS编号：403811-55-2

分子式：C12H11NOS2

分子量：249.35

MDL号：MFCD00758517

PubChem编号：1271002

英文别名：10058-F4|403811-55-2|5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone|5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one|(5E)-5-(4-ethylbenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one|10058F4|(E)-5-(4-Ethylbenzylidene)-2-mercaptothiazol-4(5H)-one|10058-

规格或纯度：≥97%

英文名称：10058-F4

生化机理：10058-F4 is a c-Myc inhibitor that prevents c-Myc/Max dimerization. c-Myc is a proto-oncogene that plays an important role in cell proliferation, differentiation, and apoptosis. 10058-F4 has been shown to arrest cell growth at G0/G1 phase. Experiments show that 10058-F4 is a c-Myc inhibitor that prevents c-Myc/Max dimerization. c-Myc is a proto-oncogene that plays an important role in cell proliferation, differentiation, and apoptosis. 10058-F4 has been shown to arrest cell growth at G0/G1 phase. Experiments show that extended exposure to 10058-F4 causes apoptosis via upregulation of Bax, expression of cytoplasmic Cytochrome C, down-regulation of Bcl-2, and cleavage of caspase-3,-7, and -9. This compound has been found to also upregulate cyclin-dependent kinase inhibitors, p21 and p27.Cell-permeable c-Myc-Max dimerization inhibitor. Downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27. Inhibits proliferation. Induces apoptosis and cell cycle arrest in G 0 /G 1 phase. Shows antitumor effects in vivo.

应用：A c-Myc inhibitor and apoptosis inducer.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：10058-F4是一种c-Myc抑制剂，特异性抑制c-Myc-Max相互作用，且抑制c-Myc靶基因表达的转录激活。A c-Myc inhibitor and apoptosis inducer.10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression.A c-Myc inhibitor and apoptosis inducer.

IUPAC Name：(5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

INCHI：InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

InChi Key：SVXDHPADAXBMFB-JXMROGBWSA-N

Canonical SMILES：CCC1=CC=C(C=C1)C=C2C(=O)NC(=S)S2

Isomeric SMILES：CCC1=CC=C(C=C1)/C=C/2\C(=O)NC(=S)S2

WGK Germany：3

PubChem CID：1271002

溶解性：Soluble in DMSO >10 mg/mL and Water <2 mg/mL

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH317 May cause an allergic skin reaction

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P501,P272,P333+P313,P362+P364,P264+P265,P337+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装