产品名称

英文名称：Cilomilast

同义词

Cilomilast、153259-65-5、Ariflo、SB-207499、SB 207499、SB207499、153259-69-9、Cilomilast-d9、trans-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid、CIS-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANECARBOXYLIC ACID、4-cyano-4-(3-c

产品性质

CAS编号：153259-65-5

分子式：C20H25NO4

分子量：343.42

PubChem编号：151170

英文别名：Cilomilast|153259-65-5|Ariflo|SB-207499|SB 207499|SB207499|153259-69-9|Cilomilast-d9|trans-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid|CIS-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANECARBOXYLIC ACID|4-cyano-4-(3-c

规格或纯度：≥98%

英文名称：Cilomilast

生化机理：Cilomilast(Ariflo, SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM). Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile sμggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.

储存温度：-20°C储存

运输条件：超低温冰袋运输

PubChem SID：488188235

IUPAC Name：4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid

INCHI：InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)

InChi Key：CFBUZOUXXHZCFB-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3

Isomeric SMILES：COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3

WGK Germany：3

PubChem CID：151170

CAS Registry No.：153259-65-5

ChEMBL Ligand：CHEMBL511115

Wikipedia：Cilomilast

RCSB PDB Ligand：CIO

溶解性：DMSO 69 mg/mL Water <1 mg/mL Ethanol 50 mg/mL

产品包装