产品名称

英文名称：AM1241

同义词

444912-48-5、AM1241、AM-1241、(2-iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)methanone、(R,S)-AM1241、DLM851L3RD、(1-(Methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole)、(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl

产品性质

CAS编号：444912-48-5

分子式：C22H22IN3O3

分子量：503.33

EC号：636-937-2

PubChem编号：10141893

英文别名：444912-48-5|AM1241|AM-1241|(2-iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)methanone|(R,S)-AM1241|DLM851L3RD|(1-(Methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole)|(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl

规格或纯度：≥98%

英文名称：AM1241

生化机理：AM-1241 is a protean agonist of CB2 based on the different effect observed in various assays (calcium influx, extracellular signal-regulated kinase (ERK) phosphorylatin and cAMP measurement)) and on the switch from neutral antagonism to agonism in the cAMP assay when forskolin concentration is lowered. In [3H]CP 55,940 competition binding assays, AM-1241 displays high affinity at the human CB2 receptor with a Ki value of about 7 nM, whereas its affinity at the human CB1 receptor is more than 80-fold weaker, using membrane preparations from stable HEK and CHO cell lines expressing the recombinant human CB2 and CB1 receptors, respectively.Potent, selective CB 2 agonist (K i = 7.1 nM). Efficacious in vivo, broad-spectrum antinociceptive effects.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.(R,S)-AM1241, a selective CB2 cannabinoid receptor agonist, has been used to study neuropathic pain in animal modelsAM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.(R,S)-AM1241, a selective CB2 cannabinoid receptor agonist, has been used to study neuropathic pain in animal models

IUPAC Name：(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone

INCHI：InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3

InChi Key：ZUHIXXCLLBMBDW-UHFFFAOYSA-N

Canonical SMILES：CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I

Isomeric SMILES：CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I

WGK Germany：3

关联CAS：444912-48-5

PubChem CID：10141893

MeSH Entry Terms：AM 1241;AM1241

溶解性：DMSO 101 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P284,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319,P342+P316

个人防护装备：dust mask type N95 (US)， Eyeshields， Faceshields， Gloves

产品包装