产品名称

英文名称：Nutlin-3

同义词

Nutlin-3、548472-68-0、890090-75-2、nutlin 3、(Rac)-Nutlin-3、4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one、(+/-)-Nutlin3、4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)p

产品性质

CAS编号：548472-68-0

分子式：C30H30Cl2N4O4

分子量：581.49

MDL号：MFCD07784509

PubChem编号：216345

英文别名：Nutlin-3|548472-68-0|890090-75-2|nutlin 3|(Rac)-Nutlin-3|4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one|(+/-)-Nutlin3|4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)p

规格或纯度：≥98%

英文名称：Nutlin-3

生化机理：Nutlin-3, the racemic and most commonly used form of nutlin, inhibits p53-MDM2 interaction. It has shown ability to induce the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. When in combination with perifosine, anti-leukaemic activity has been observed. High N-MYC (MycN) expression has been induced in non-N-MYC-amplified neuroblastoma cells when treated with the combination of nutlin-3 and doxorubicin.Potent, selective MDM2 antagonist; inhibits the MDM2-p53 interaction (IC 50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nutlin-3是一种有效的，选择性的Mdm2(依赖环指状的泛素蛋白连接酶和p53)拮抗剂，IC50为90 nM。可稳定p53缺陷的细胞中的p73。Disrupts MDM2-p53 interaction, inducing apoptosis.Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM; stabilizes p73 in p53-deficient cells.Disrupts MDM2-p53 interaction, inducing apoptosis.

IUPAC Name：4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

INCHI：InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)

InChi Key：BDUHCSBCVGXTJM-UHFFFAOYSA-N

Canonical SMILES：CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Isomeric SMILES：CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

WGK Germany：3

PubChem CID：216345

溶解性：Soluble in ethanol (25 mg/ml), DMSO (20 mg/ml), DMF, methanol, and acetonitrile. Insoluble in water. Sparingly soluble in ethanolPBS pH 7.2 (110).

敏感性：对热敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装