产品名称

英文名称：Pirodavir

同义词

ethyl 4-(2-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)ethoxy)benzoate、Acetosulfamin、Pirodavirum、Pirodavir (USAN/INN)、Sulfacitinum、BDBM50087765、4-{2-[1-(6-Methyl-pyridazin-3-yl)-piperidin-4-yl]-ethoxy}-benzoic acid ethyl ester (Pirodavir)、HY-13784、(METHYLPY、吡罗达韦

产品性质

CAS编号：124436-59-5

分子式：C21H27N3O3

分子量：369.46

MDL号：MFCD00866965

PubChem编号：71345

别名：吡罗达韦

英文别名：ethyl 4-(2-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)ethoxy)benzoate|Acetosulfamin|Pirodavirum|Pirodavir (USAN/INN)|Sulfacitinum|BDBM50087765|4-{2-[1-(6-Methyl-pyridazin-3-yl)-piperidin-4-yl]-ethoxy}-benzoic acid ethyl ester (Pirodavir)|HY-13784|(METHYLPY

规格或纯度：≥98%

英文名称：Pirodavir

生化机理：Description IC50 Value Pirodavir inhibits 80 percentage of viruses at 0.064 micrograms/ml(EC80)[2]. pirodavir was one of the most promising capsid-binding compounds to show efficacy in human clinical trials for chemoprophylaxis of the common cold. Susceptibility to hydrolysis precluded its use as an oral agent [1]. in vitro R-77975's predecessor, R 61837, a substituted phenyl-pyridazinamine, was effective in inhibiting 80% of 100 serotypes tested (EC80) at concentrations above 32 micrograms/ml, pirodavir inhibits the same percentage of viruses at 0.064 micrograms/ml. Pirodavir is also effective in inhibiting 16 enteroviruses, with an EC80 of 1.3 micrograms/ml. Pirodavir acts at an early stage of the viral replication cycle (up to 40 min after infection) and reduces the yield of selected rhinoviruses 1,000- to 100,000-fold in a single round of replication [2]. in vivo Adults with symptoms of < or = 2 days' duration were randomly assigned to intranasal spr

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Pirodavir（R 77975）是一类新型广谱抗小核糖核酸病毒化合物的原型，是人鼻病毒HRV外壳结合抑制剂。Pirodavir (R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds; potent human rhinovirus (HRV) capsid-binding inhibitor.

ALogP：3.7

IUPAC Name：ethyl 4-[2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy]benzoate

INCHI：InChI=1S/C21H27N3O3/c1-3-26-21(25)18-5-7-19(8-6-18)27-15-12-17-10-13-24(14-11-17)20-9-4-16(2)22-23-20/h4-9,17H,3,10-15H2,1-2H3

InChi Key：KCHIOGFOPPOUJC-UHFFFAOYSA-N

Canonical SMILES：CCOC(=O)C1=CC=C(C=C1)OCCC2CCN(CC2)C3=NN=C(C=C3)C

Isomeric SMILES：CCOC(=O)C1=CC=C(C=C1)OCCC2CCN(CC2)C3=NN=C(C=C3)C

PubChem CID：71345

溶解性：25°C DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 7 mg/mL

敏感性：对热敏感

熔点：125 °C

产品包装