产品名称

英文名称：Hydralazine HCl

同义词

HYDRALAZINE HYDROCHLORIDE、304-20-1、HYDRALAZINE HCL、Apresoline、1-Hydrazinophthalazine hydrochloride、1-Hydrazinylphthalazine hydrochloride、Aiselazine、Dralzine、Hyperazin、Hyperex、Lopress、Hydralazine chloride、Slow-Apresolin、Apresine、Rolazine、Hydralazine monohy、盐酸肼屈嗪、1-肼基-2,3-二氮杂萘盐酸盐

产品性质

CAS编号：304-20-1

分子式：C8H8N4·HCl

分子量：196.64

EC号：206-151-0

MDL号：MFCD00135998

PubChem编号：9351

别名：盐酸肼屈嗪|1-肼基-2,3-二氮杂萘盐酸盐

英文别名：HYDRALAZINE HYDROCHLORIDE|304-20-1|HYDRALAZINE HCL|Apresoline|1-Hydrazinophthalazine hydrochloride|1-Hydrazinylphthalazine hydrochloride|Aiselazine|Dralzine|Hyperazin|Hyperex|Lopress|Hydralazine chloride|Slow-Apresolin|Apresine|Rolazine|Hydralazine monohy

规格或纯度：≥99%

英文名称：Hydralazine HCl

生化机理：1-Hydrazinophthalazine Hydrochloride is a DNA methyltransferase (Dnmt) inhibitor which modulates epigenetic regulation of gene expression. 1-Hydrazinophthalazine Hydrochloride also acts as a non-selective MAO-A/B inhibitor and semicarbazide sensitive amine oxidase inhibitor.Inhibits DNA methylation by inhibition of MAPK (EC 50 = 2.96 μM). Multiple, direct effects on vascular smooth muscle; hyperpolarization, inhibition of IP 3 -induced release of Ca 2+ and formation of NO leading to cGMP-mediated vasodilation.

应用：An inhibitor of Dnmt, MAO-A/B, and amine oxidase.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Hydralazine HCl 是Hydralazine (Apresoline) 的盐酸盐形式，是直接有效的平滑肌松弛剂，IC50为1.9 mM。An inhibitor of Dnmt, MAO-A/B, and amine oxidase.Hydralazine HCl is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.An inhibitor of Dnmt, MAO-A/B, and amine oxidase.

IUPAC Name：phthalazin-1-ylhydrazine;hydrochloride

INCHI：InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H

InChi Key：ZUXNZUWOTSUBMN-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C=NN=C2NN.Cl

Isomeric SMILES：C1=CC=C2C(=C1)C=NN=C2NN.Cl

WGK Germany：3

RTECS：TH9000000

PubChem CID：9351

Reaxy-Rn：3568329

溶解性：DMSO Water 1 mg/mL Ethanol >

熔点：273°C(dec.)(lit.)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH341 Suspected of causing genetic defectsH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH371 May cause damage to organs

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P284,P281,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P316,P318,P337+P317,P308+P316,P332+P317,P319,P342+P316

Merck Index：4763

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装