产品名称

英文名称：Licochalcone A

同义词

licochalcone a、58749-22-7、Licochalcone-A、LicochalconeA、(E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one、(E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one、CHEMBL1397、甘草查耳酮甲、(E)-(E)-3- [5-(1,1-二甲基-2-丙烯基)-4-羟基-2-甲氧基苯基]-1-(4-羟基苯基)-2-丙烯-1-酮、4'1,4-二羟基-3-α,α-二甲基烯丙基-6-甲氧基查尔酮、(2E)-3-[4-羟基-2-甲氧基-5-(2-甲基-3-丁烯-2-基)苯基]-1-(4-羟基苯基)-2-丙烯-1-酮

产品性质

CAS编号：58749-22-7

分子式：C21H22O4

分子量：338.4

MDL号：MFCD01417903

PubChem编号：5318998

别名：甘草查耳酮甲|(E)-(E)-3- [5-(1,1-二甲基-2-丙烯基)-4-羟基-2-甲氧基苯基]-1-(4-羟基苯基)-2-丙烯-1-酮|4'1,4-二羟基-3-α,α-二甲基烯丙基-6-甲氧基查尔酮|(2E)-3-[4-羟基-2-甲氧基-5-(2-甲基-3-丁烯-2-基)苯基]-1-(4-羟基苯基)-2-丙烯-1-酮

英文别名：licochalcone a|58749-22-7|Licochalcone-A|LicochalconeA|(E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one|(E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one|CHEMBL1397

规格或纯度：≥96%

英文名称：Licochalcone A

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：Licochalcone A 是一种强效膜活性剂，可将正常红细胞转化为棘形红细胞。一种具有显著抗肿瘤活性的新型黄酮类化合物。生化/生理作用抑制芽孢形成细菌 枯草芽孢杆菌 和其他食品污染微生物的营养生长。Licochalcone A, Synthetic is an estrogenic flavanoid originally derived from licorice root (Glycyrrhiza glabra). Licochalcone-A has displayed the ability to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Licochalcone-A also induces cell differentiation, exhibits antibacterial, antiinflammatory and antitumor activity. It has been reported to interfere with parasite mitochondrial electron transport chain and energy metabolism, and also to inhibitin vitro growth of the human malaria parasite Plasmodium falciparum. There is also evidence that licochalcone-A can regulate rat vascular smooth muscle cell proliferation.

IUPAC Name：(E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one

INCHI：InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+

InChi Key：KAZSKMJFUPEHHW-DHZHZOJOSA-N

Canonical SMILES：CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O

Isomeric SMILES：CC(C)(C=C)C1=C(C=C(C(=C1)/C=C/C(=O)C2=CC=C(C=C2)O)OC)O

PubChem CID：5318998

溶解性：≥33.8 mg/mL in DMSO; insoluble in H2O; ≥52.5 mg/mL in EtOH

敏感性：对空气敏感；对热敏感

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaled

预防措施声明：P261,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P301+P317,P317

Merck Index：5479

产品包装