产品名称

英文名称：Acetylsalicylic acid

同义词

ASA、Acesal、Acetisal、Aspirdrops、Solpyron、A.S.A. empirin、Acetosal、Benaspir、Contrheuma retard、Acido acetilsalicilico、Bayer、Entericin、Kyselina 2-acetoxybenzoova、8-hour Bayer、Acetylsalicylsaeure、Benzoic acid, 2-(acetyloxy)-、o-Carboxyphenyl acetate、Saletin、Aspr、阿司匹林

产品性质

CAS编号：50-78-2

分子式：C9H8O4

分子量：180.16

Beilstein号：779271

EC号：200-064-1

MDL号：MFCD00002430

PubChem编号：2244

别名：阿司匹林

英文别名：ASA|Acesal|Acetisal|Aspirdrops|Solpyron|A.S.A. empirin|Acetosal|Benaspir|Contrheuma retard|Acido acetilsalicilico|Bayer|Entericin|Kyselina 2-acetoxybenzoova|8-hour Bayer|Acetylsalicylsaeure|Benzoic acid, 2-(acetyloxy)-|o-Carboxyphenyl acetate|Saletin|Aspr

规格或纯度：99%

英文名称：Acetylsalicylic acid

生化机理：环氧合酶（COX）-1抑制剂。阻止前列腺素和血栓烷的产生。表现出抗血小板和抗血栓形成的活性。在某些实体瘤中显示出抗癌作用。最早描述的NSAID药物之一。

应用：检定锰。有机合成。 乙酰水杨酸靠抑制环化加氧酶（cyclooxygenase，前列腺素H合成酶)阻止前列腺索的生产，特别是针对COX-1同种型有很高的选择性。其抗血栓效果就是由于抑制了血小板中起凝血和血小板凝聚作用的COX-1。

储存温度：干燥

运输条件：常规运输

产品介绍：无气味。微带酸味。在干燥空气中稳定，在潮湿空气中逐渐水解成水杨酸和乙酸。遇沸水或溶于氢氧化钠碱溶液和碳酸碱溶液中全部分解。溶于乙醇、乙醚和氯仿。检定锰。有机合成。 乙酰水杨酸靠抑制环化加氧酶（cyclooxygenase，前列腺素H合成酶)阻止前列腺索的生产，特别是针对COX-1同种型有很高的选择性。其抗血栓效果就是由于抑制了血小板中起凝血和血小板凝聚作用的COX-1。Aspirin is an antiinflammatory compound that inhibits NFκB, cylooxygenase-1 (Cox-1), and cyclooxygenase-2 (Cox-2). NFκB is a transcription factor that plays an important role in the expression of cellular and viral genes, which regulate the inflammatory response and infection. Adhesion molecules IL-1 and IL-6 are genes regulated by NFκB. Along with sodium salicylate, aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription. Research indicates that aspirin acts at a site downstream of glutamate receptors and blocks induction of NFκB mediated by glutamate. Additional studies suggest that aspirin and sodium salicylate specifically inhibit IKKβ, which results in the blocking of NFκB genes responsible for the inflammatory response. Aspirin has also been described to elevate extracellular adenosine levels, downregulate the expression and activity of inducible NOS, decrease the levels of adenosine triphosphate, act on multiple mitogen-activated protein kinase activities, and block the uncoupling of oxidative phosphorylation. Studies reveal that aspirin alters the equilibrium of Mcl-1/Noxa, giving rise to apoptosis of leukemia cells, independent of NFκB and MAPKs.An inhibitor of COX-1 (cylooxygenase) and NFκB.

ALogP：1.2

PubChem SID：488179680

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179680

IUPAC Name：2-acetyloxybenzoic acid

INCHI：InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChi Key：BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Canonical SMILES：CC(=O)OC1=CC=CC=C1C(=O)O

Isomeric SMILES：CC(=O)OC1=CC=CC=C1C(=O)O

WGK Germany：1

RTECS：VO0700000

PubChem CID：2244

UN Number：2811

Packing Group：I

Reaxy-Rn：779271

溶解性：溶于water, 最高浓度 (mg/mL) 1.8, 最高浓度(mM) 10；溶于DMSO, 最高浓度 (mg/mL) 18.02, 最高浓度(mM) 100

密度：1.35

敏感性：对湿度敏感

闪点(℉)：446 °F

闪点(℃)：250℃

熔点：136-140°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

Class：6.1

Merck Index：851

个人防护装备：dust mask type N95 (US),Eyeshields,Faceshields,Gloves

产品包装