产品名称

英文名称：1-deoxysphinganine (m180)

同义词

Spisulosine、196497-48-0、(2S,3R)-2-aminooctadecan-3-ol、1-deoxysphinganine、(+)-Spisulosine、Spisulosine 285、1-deoxy-sphinganine、ES-285、Spisulosine [WHO-DD]、3-Octadecanol, 2-amino-, (2S,3R)-、CHEBI67106、2S-amino-octadecan-3R-ol、ZX5D253CYY、CHEMBL1835439、3-Octa

产品性质

CAS编号：196497-48-0

分子式：C18H39NO

分子量：285.508

PubChem编号：9925886

英文别名：Spisulosine|196497-48-0|(2S,3R)-2-aminooctadecan-3-ol|1-deoxysphinganine|(+)-Spisulosine|Spisulosine 285|1-deoxy-sphinganine|ES-285|Spisulosine [WHO-DD]|3-Octadecanol, 2-amino-, (2S,3R)-|CHEBI67106|2S-amino-octadecan-3R-ol|ZX5D253CYY|CHEMBL1835439|3-Octa

规格或纯度：99%

英文名称：1-deoxysphinganine (m180)

生化机理：1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT). It is metabolized to 1-deoxyceramides.Application1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8+ T cells.

IUPAC Name：(2S,3R)-2-aminooctadecan-3-ol

INCHI：InChI=1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18+/m0/s1

InChi Key：YRYJJIXWWQLGGV-ZWKOTPCHSA-N

Canonical SMILES：CCCCCCCCCCCCCCCC(C(C)N)O

Isomeric SMILES：CCCCCCCCCCCCCCC[C@H]([C@H](C)N)O

PubChem CID：9925886

产品包装