产品名称

英文名称：CVT-313

同义词

CVT-313、199986-75-9、Cdk2 Inhibitor III、CVT 313、NG-36、CHEMBL80713、T5490K8I7S、2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine、2,2'-((9-Isopropyl-6-((4-methoxybenzyl)amino)-9H-purin-2-yl)azanediyl)diethanol、2,2'-((9-isopropyl-6-((4-met、Cdk2 Inhibitor III)、2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine、CVT-313、Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem、2( bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purineCVT-313 (Cdk2 Inhibitor III) 是一种有效的

产品性质

CAS编号：199986-75-9

分子式：C20H28N6O3

分子量：400.47

PubChem编号：6918386

别名：Cdk2 Inhibitor III)|2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine|CVT-313|Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem|2( bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purineCVT-313 (Cdk2 Inhibitor III) 是一种有效的

英文别名：CVT-313|199986-75-9|Cdk2 Inhibitor III|CVT 313|NG-36|CHEMBL80713|T5490K8I7S|2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine|2,2'-((9-Isopropyl-6-((4-methoxybenzyl)amino)-9H-purin-2-yl)azanediyl)diethanol|2,2'-((9-isopropyl-6-((4-met

规格或纯度：98%

英文名称：CVT-313

生化机理：CVT-313 is a cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 ?M for Cdk2/A and Cdk2/E; 4.2 ?M for Cdk1/B; 215 ?M for Cdk4/D1). CVT-313 inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). CVT-313 shown to induce tumor cells growth arrest (IC50 ~1.25-20 ?M) in vitro and prevent neointima formation in vivo.Potent and selective CDK2 inhibitor (IC 50 ranging between 1.25 µM to 20 µM).\xa0Inhibition is competitive with respect to ATP (Ki = 95 nM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：产品介绍CVT-313 (Cdk2 Inhibitor III) 是一种有效的ATP-竞争性的选择性 CDK2 抑制剂，IC50 为0.5 μM。CVT-313 可抑制 CDC5L 磷酸化。Product DescriptionCVT-313 is apotent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases.

IUPAC Name：2-[2-hydroxyethyl-[6-[(4-methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]ethanol

INCHI：InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)

InChi Key：NQVIIUBWMBHLOZ-UHFFFAOYSA-N

Canonical SMILES：CC(C)N1C=NC2=C(N=C(N=C21)N(CCO)CCO)NCC3=CC=C(C=C3)OC

Isomeric SMILES：CC(C)N1C=NC2=C(N=C(N=C21)N(CCO)CCO)NCC3=CC=C(C=C3)OC

PubChem CID：6918386

ChEMBL Ligand：CHEMBL80713

CAS Registry No.：199986-75-9

RCSB PDB Ligand：AJR

溶解性：DMSO Ethanol

产品包装