产品名称

英文名称：Apixaban

同义词

FT-0686944、SCHEMBL118023、1H-PYRAZOLO(3,4-C)PYRIDINE-3-CARBOXAMIDE, 4,5,6,7-TETRAHYDRO-1-( 4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-、1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carbox、阿哌沙班

产品性质

CAS编号：503612-47-3

分子式：C25H25N5O4

分子量：459.51

EC号：639-684-6

PubChem编号：10182969

别名：阿哌沙班

英文别名：FT-0686944|SCHEMBL118023|1H-PYRAZOLO(3,4-C)PYRIDINE-3-CARBOXAMIDE, 4,5,6,7-TETRAHYDRO-1-( 4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-|1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carbox

规格或纯度：≥99%

英文名称：Apixaban

生化机理：Apixaban(BMS-562247-01; BMS 562247-01) is a direct factor Xa inhibitor with an IC50 of 0.22±0.02 μM. Apixaban is a compound being investigated as an anticoagulant. Apixaban (BMS-562247-01; BMS 562247-01)has similar affinity for human and rabbit factor Xa (FXa).

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Apixaban是一种高度选择性，可逆的凝血因子 Xa 抑制剂，抑制人和兔凝血因子 Xa 的 Ki 值分别为 0.08 nM 和 0.17 nM。Apixaban 正在开发用于预防和治疗各种血栓栓塞疾病。Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases.

ALogP：2.2

PubChem SID：488196571

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488196571

IUPAC Name：1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide

INCHI：InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)

InChi Key：QNZCBYKSOIHPEH-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N

Isomeric SMILES：COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N

关联CAS：503612-47-3

PubChem CID：10182969

MeSH Entry Terms：apixaban;BMS 562247;BMS-562247;BMS-562247-01;BMS562247;Eliquis

ChEMBL Ligand：CHEMBL231779

CAS Registry No.：503612-47-3

ChEBI：CHEBI72296

DrugBank Ligand：DB06605

Wikipedia：Apixaban

RCSB PDB Ligand：GG2

PEP：apixaban

Reactome Reaction：R-HSA-9015122, R-HSA-9015111

Reactome Drug：R-ALL-9038732

DrugCentral Ligand：4298

溶解性：DMSO 18 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P501,P264,P260,P270,P319

产品包装