产品名称

英文名称：Tiagabine hydrochloride

同义词

Tiagabine hydrochloride、145821-59-6、TIAGABINE HCl、Gabitril、Abbott 70569.HCl、Abbott-70569.1、NNC-05-0328、NO-05-0328、ABBOTT-70569.HCL、(r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride、ABT-569、Tiagabine (hydrochlori、噻加宾盐酸盐、噻加宾盐酸盐、盐酸噻加宾

产品性质

CAS编号：145821-59-6

分子式：C20H25NO2S2 · HCl

分子量：412

MDL号：MFCD07369025

PubChem编号：91274

别名：噻加宾盐酸盐|噻加宾盐酸盐|盐酸噻加宾

英文别名：Tiagabine hydrochloride|145821-59-6|TIAGABINE HCl|Gabitril|Abbott 70569.HCl|Abbott-70569.1|NNC-05-0328|NO-05-0328|ABBOTT-70569.HCL|(r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride|ABT-569|Tiagabine (hydrochlori

规格或纯度：≥98%(HPLC)

英文名称：Tiagabine hydrochloride

生化机理：GABA吸收抑制剂（体内IC50 = 67 nMin）。对GAT-1 GABA转运蛋白具有高亲和力和选择性。抗惊厥药;全身性给药后，还可减轻小鼠模型中已建立的强啡肽诱发的异常性疼痛。

应用：Tiagabine hydrochloride was used to study serotoninergic transmission in G1 cells.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Tiagabine（NO328）盐酸盐是GABA重吸收抑制剂Tiagabine hydrochloride was used to study serotoninergic transmission in G1 cells.Tiagabine hydrochloride(NO328 hydrochloride) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.Tiagabine hydrochloride was used to study serotoninergic transmission in G1 cells.

IUPAC Name：(3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride

INCHI：InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1

InChi Key：YUKARLAABCGMCN-PKLMIRHRSA-N

Canonical SMILES：CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl

Isomeric SMILES：CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C.Cl

WGK Germany：3

PubChem CID：91274

溶解性：溶于water, 最高浓度 (mg/mL) 20.6, 最高浓度(mM) 50；溶于DMSO, 最高浓度 (mg/mL) 41.2, 最高浓度(mM) 100

敏感性：吸湿、对热敏感

比旋光度：-11° (C=1.0,H2O)

熔点：193 °C

Merck Index：9417

产品包装