产品名称

英文名称：Cyclosporin A

同义词

cyclosporin A、cyclosporine、Ciclosporin、59865-13-3、Cyclosporin、Sandimmune、Cyclosporine A、Neoral、Sandimmun、Ramihyphin A、Ciclosporine、Equoral、Gengraf、Neoplanta、Sang-35、Ciclosporinum、Sandimmun Neoral、Zinograf ME、Ciclosporina、Consupren、Mitogard、Optimmune、Ciclo、环孢菌素A、环孢菌素、抗生素 S 7481F1、环孢素、环孢素A、环孢多肽A、环孢灵、赛斯平

产品性质

CAS编号：59865-13-3

分子式：C62H111N11O12

分子量：1202.61

Beilstein号：3647785

MDL号：MFCD00274558

PubChem编号：5284373

别名：环孢菌素A|环孢菌素|抗生素 S 7481F1|环孢素|环孢素A|环孢多肽A|环孢灵|赛斯平

英文别名：cyclosporin A|cyclosporine|Ciclosporin|59865-13-3|Cyclosporin|Sandimmune|Cyclosporine A|Neoral|Sandimmun|Ramihyphin A|Ciclosporine|Equoral|Gengraf|Neoplanta|Sang-35|Ciclosporinum|Sandimmun Neoral|Zinograf ME|Ciclosporina|Consupren|Mitogard|Optimmune|Ciclo

规格或纯度：98%

英文名称：Cyclosporin A

应用：抑制T细胞受体信号传导路径,用于分子生物学研究。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：25mg卖完停产，不再备货

产品介绍：产品介绍 Cyclosporin A (Cyclosporine A) 是一种免疫抑制剂，能与亲环素结合，抑制 calcineurin 活性的IC50 值为 7 nM。Cyclosporin A 也抑制 CD11a/CD18 粘附分子。无臭无味。抑制T细胞受体信号传导路径,用于分子生物学研究。

ALogP：7.5

IUPAC Name：(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

INCHI：InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChi Key：PMATZTZNYRCHOR-CGLBZJNRSA-N

Canonical SMILES：CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Isomeric SMILES：CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

WGK Germany：3

RTECS：GZ4120000

PubChem CID：5284373

Reaxy-Rn：3647785

Wikipedia：Cyclosporin

CAS Registry No.：59865-13-3

DrugBank Ligand：DB00091

ChEBI：CHEBI4031

ChEMBL Ligand：CHEMBL160

PEP：cyclosporin a

Immunopaedia Search：cyclosporin A

DrugCentral Ligand：760

GPCRdb Ligand：cyclosporin A

溶解性：极易溶于乙醚、丙酮、甲醇、乙醇；可溶于氯仿

密度：1.016

敏感性：对热敏感 ;对光线敏感

比旋光度：-193 ° (C=0.5, MeOH)

熔点：151°C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH350 May cause cancer

预防措施声明：P280,P405,P501,P264,P260,P270,P330,P203,P301+P317,P318,P319

Merck Index：2752

个人防护装备：Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装