产品名称

英文名称：IB-MECA

同义词

IB-MECA、piclidenoson、152918-18-8、CF-101、3-IB-Meca、CF 101、N(6)-Ibamu、Cf101、N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine、Piclidenoson [USAN]、1-Deoxy-1-(6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-N-methyl-beta-D-ribofuranuronamide、N6-(3-Iodobenzyl、N6-(3-碘苄基)腺苷-5'-N-甲基糖酰胺

产品性质

CAS编号：152918-18-8

分子式：C18H19IN6O4

分子量：510.29

PubChem编号：123683

别名：N6-(3-碘苄基)腺苷-5'-N-甲基糖酰胺

英文别名：IB-MECA|piclidenoson|152918-18-8|CF-101|3-IB-Meca|CF 101|N(6)-Ibamu|Cf101|N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine|Piclidenoson [USAN]|1-Deoxy-1-(6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-N-methyl-beta-D-ribofuranuronamide|N6-(3-Iodobenzyl

规格或纯度：98% (HPLC)

英文名称：IB-MECA

生化机理：Selective A3 adenosine receptor agonist.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Piclidenoson (IB-MECA;CF-101) is afirst-in-class, orally bioavailable and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19.IB-MECA has been used for intraocular pressure and corneal thickness measurements in rabbits.Piclidenoson (IB-MECA;CF-101) is afirst-in-class, orally bioavailable and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19.IB-MECA has been used for intraocular pressure and corneal thickness measurements in rabbits.

IUPAC Name：(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methyloxolane-2-carboxamide

INCHI：InChI=1S/C18H19IN6O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-3-2-4-10(19)5-9/h2-5,7-8,12-14,18,26-27H,6H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/m0/s1

InChi Key：HUJXGQILHAUCCV-MOROJQBDSA-N

Canonical SMILES：CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=CN=C32)NCC4=CC(=CC=C4)I)O)O

Isomeric SMILES：CNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)NCC4=CC(=CC=C4)I)O)O

PubChem CID：123683

ChEBI：CHEBI73286

ChEMBL Ligand：CHEMBL119709

BindingDB Ligand：50118812

CAS Registry No.：152918-18-8

GPCRdb Ligand：piclidenoson

RCSB PDB Ligand：Q8L

溶解性：ethanol >10 mg/mL (hot) DMSO >5 mg/mL H2O insoluble aqueous acid insoluble aqueous base insoluble

产品包装