产品名称

英文名称：4-Hydroxyquinazoline

同义词

4-Hydroxyquinazoline、491-36-1、Quinazolin-4-ol、4-Quinazolinol、quinazolin-4(3H)-one、4(3H)-Quinazolinone、4-Quinazolinone、4-Quinazolone、4(1H)-Quinazolinone、4-HQN、3,4-Dihydroquinazolin-4-one、4-Oxoquinazoline、4(3H)-Quinazolone、1H-quinazolin-4-one、132305-20-5、Qu、4-喹唑酮、4-喹唑啉醇

产品性质

CAS编号：491-36-1

分子式：C8H6N2O

分子量：146.15

Beilstein号：24143

MDL号：MFCD00511302

PubChem编号：135408753

别名：4-喹唑酮|4-喹唑啉醇

英文别名：4-Hydroxyquinazoline|491-36-1|Quinazolin-4-ol|4-Quinazolinol|quinazolin-4(3H)-one|4(3H)-Quinazolinone|4-Quinazolinone|4-Quinazolone|4(1H)-Quinazolinone|4-HQN|3,4-Dihydroquinazolin-4-one|4-Oxoquinazoline|4(3H)-Quinazolone|1H-quinazolin-4-one|132305-20-5|Qu

规格或纯度：≥98.0%(HPLC)

英文名称：4-Hydroxyquinazoline

运输条件：常规运输

产品介绍：Product Application4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

PubChem SID：488202850

IUPAC Name：3H-quinazolin-4-one

INCHI：InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)

InChi Key：QMNUDYFKZYBWQX-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C(=O)NC=N2

Isomeric SMILES：C1=CC=C2C(=C1)C(=O)NC=N2

WGK Germany：3

RTECS：VA2300000

PubChem CID：135408753

Reaxy-Rn：607148

溶解性：Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

敏感性：易吸潮

熔点：215.0 ~220.0 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装