产品名称

英文名称：ABT-737

同义词

ABT-737、852808-04-9、ABT 737、ABT737、UNII-Z5NFR173NV、4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide、Z5NFR173NV、(R)-4-(4-((4'-chloro-[1,1'-biphen

产品性质

CAS编号：852808-04-9

分子式：C42H45ClN6O5S2

分子量：813.43

PubChem编号：11228183

英文别名：ABT-737|852808-04-9|ABT 737|ABT737|UNII-Z5NFR173NV|4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide|Z5NFR173NV|(R)-4-(4-((4'-chloro-[1,1'-biphen

规格或纯度：≥97%

英文名称：ABT-737

生化机理：ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance, inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells.BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor. Triggers Bax/Bak-mediated apoptosis (EC 50 values are 79, 30 and 198 nM for Bcl-xL, Bcl-2 and Bcl-w mediated apoptosis respectively). Shows antitumor effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：ABT-737是 Bcl-xL, Bcl-2 和 Bcl-w抑制剂，EC50分别为78.7 nM，30.3 nM和197.8 nM。对Mcl-1， Bcl-B 和 Bfl-1无抑制性。A selective inhibitor of Bcl-2ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1.A selective inhibitor of Bcl-2

IUPAC Name：4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide

INCHI：InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1

InChi Key：HPLNQCPCUACXLM-PGUFJCEWSA-N

Canonical SMILES：CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

Isomeric SMILES：CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

PubChem CID：11228183

CAS Registry No.：852808-04-9

ChEMBL Ligand：CHEMBL376408

RCSB PDB Ligand：N3C

溶解性：DMSO ≥160mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

密度：1.4

折光率：1.7

熔点：148-151°C

产品包装