产品名称

英文名称：Digitoxin

同义词

NCGC00096198-01 、 CAS-71-63-6 、 Digitalis 、 Digicor 、 Digitoxigenin tridigitoxoside 、 DigitoXin, USP 、 Mono-digitoxid 、 HSDB 215 、 Monodigitoxoside 、 Purpurid 、 Digitoxina [INN-Spanish] 、 Lanatoxin 、 SMR000058529 、 Digitoxine [INN-French] 、 cid_441207 、 D、肉豆蔻酸、洋地黄毒甙

产品性质

CAS编号：71-63-6

分子式：C41H64O13

分子量：764.94

Beilstein号：76678

EC号：200-760-5

MDL号：MFCD00003686

PubChem编号：441207

别名：肉豆蔻酸|洋地黄毒甙

英文别名：NCGC00096198-01 | CAS-71-63-6 | Digitalis | Digicor | Digitoxigenin tridigitoxoside | DigitoXin, USP | Mono-digitoxid | HSDB 215 | Monodigitoxoside | Purpurid | Digitoxina [INN-Spanish] | Lanatoxin | SMR000058529 | Digitoxine [INN-French] | cid_441207 | D

规格或纯度：≥92% (HPLC)

英文名称：Digitoxin

运输条件：常规运输

产品介绍：产品介绍洋地黄毒苷是一种强心苷（CG）。它是一种强心药，表现出心脏 和抗癌特性。洋地黄毒苷可抑制核因子κB（NF-κB）信号转导。它可用于治疗充血性心力衰竭和心律不齐。洋地黄毒苷可以防止微管形成。 应用洋地黄毒苷已被用作人类血清白蛋白（HSA）上结合位点的标记药物。它还已被用于测定其抗传播性胃肠炎病毒（TGEV）的活性。Digitoxin is a cardiac glycoside (CG). It is a cardiotonic drug, which exhibits cardiac and anti-cancer properties. Digitoxin inhibits nuclear factor kappa B (NF-κB) signaling. It is used to treat congestive heart failure and cardiac arrhythmia. Digitoxin prevents microtubule formation.ApplicationDigitoxin has been used as a labeled drugs for binding sites on human serum albumin (HSA).[5][6] It has also been used to test its anti-transmissible gastroenteritis virus (TGEV) activity.

IUPAC Name：3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

INCHI：InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27+,28-,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

InChi Key：WDJUZGPOPHTGOT-XUDUSOBPSA-N

Canonical SMILES：CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O

Isomeric SMILES：C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O

WGK Germany：3

RTECS：IH2275000

PubChem CID：441207

UN Number：2811

Packing Group：I

DrugBank Ligand：DB01396

CAS Registry No.：71-63-6

ChEMBL Ligand：CHEMBL254219

ChEBI：CHEBI28544

Wikipedia：Digitoxin

RCSB PDB Ligand：F9R

Reactome Reaction：R-HSA-9684068

Reactome Drug：R-ALL-9684077

DrugCentral Ligand：881

溶解性：soluble in chloroform

熔点：240 °C (dec.) (lit.)

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH331 Toxic if inhaledH373 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P261,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P330,P301+P316,P316,P319

Class：6.1

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装