产品名称

英文名称：Kaempferol

同义词

kaempferol、520-18-3、Robigenin、Kaempherol、Kempferol、Populnetin、Rhamnolutein、Trifolitin、Swartziol、Pelargidenolon、Rhamnolutin、3,4',5,7-Tetrahydroxyflavone、Indigo Yellow、Kampherol、Campherol、Kampferol、Nimbecetin、3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-、莰菲醇,山柰酚,山柰素

产品性质

CAS编号：520-18-3

分子式：C15H10O6

分子量：286.24

Beilstein号：304401

MDL号：MFCD00016938

PubChem编号：5280863

别名：莰菲醇,山柰酚,山柰素

英文别名：kaempferol|520-18-3|Robigenin|Kaempherol|Kempferol|Populnetin|Rhamnolutein|Trifolitin|Swartziol|Pelargidenolon|Rhamnolutin|3,4',5,7-Tetrahydroxyflavone|Indigo Yellow|Kampherol|Campherol|Kampferol|Nimbecetin|3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-

规格或纯度：分析标准品,≥98%

英文名称：Kaempferol

生化机理：Description IC50 value Kaempferol inhibits proliferation of ovarian cancer cells at 40μM or higher concentrations[2]. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a relatively common nontoxic, natural dietary compound which has been reported to reduce the risk of ovarian cancer[1]. in vitro Kaempferol was found to inhibit estrogen receptor alpha expression in breast cancer cells and to induce apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Studies have shown that kaempferol also has anti-inflammatory effects via inhibition of interleukin-4 and cyclo-oxygenase 2 expression by suppressing Src kinase and downregulating the NFκB pathway. Kaempferol is also effective in inhibiting angiogenesis and inducing apoptosis in ovarian cancer cells [1]. kaempferol has a distinct epigenetic activity by inhibition of histone deacetylases (HDACs). In silico docking analysis revealed that it fits into the bindin

应用：一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-H-ras-转化的 NIH 3T3细胞变形后的恢复。能显著诱导核DNA退化，同时伴随脂类的过氧化反应。抑制拓扑异构酶I催化的DNA再连接。

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-H-ras-转化的 NIH 3T3细胞变形后的恢复。能显著诱导核DNA退化，同时伴随脂类的过氧化反应。抑制拓扑异构酶I催化的DNA再连接。

IUPAC Name：3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one

INCHI：InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

InChi Key：IYRMWMYZSQPJKC-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

Isomeric SMILES：C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

RTECS：LK9275200

PubChem CID：5280863

Reaxy-Rn：304401

RCSB PDB Ligand：KMP

CAS Registry No.：520-18-3

ChEMBL Ligand：CHEMBL150

ChEBI：CHEBI28499

DrugBank Ligand：DB01852

Wikipedia：Kaempferol

Antibiotic DB：1257

密度：1.688

敏感性：对光线敏感；对空气敏感

熔点：276°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH341 Suspected of causing genetic defects

预防措施声明：P321,P405,P501,P264,P281,P270,P330,P203,P301+P316,P318

Merck Index：5274

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

产品包装