产品名称

英文名称：Diclofenac

同义词

diclofenac、Diclofenac acid、15307-86-5、dichlofenac、Diclofenacum、Diclophenac、Diclofenaco、ProSorb-D、2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid、Diclofenac resinate、Voltarol、Diclofenac free acid、2-(2,6-Dichloroanilino)phenylacetic Acid、Zorovolex、Zorvol、双氯芬酸、奥尔芬

产品性质

CAS编号：15307-86-5

分子式：C14H11Cl2NO2

分子量：296.15

PubChem编号：3033

别名：双氯芬酸|奥尔芬

英文别名：diclofenac|Diclofenac acid|15307-86-5|dichlofenac|Diclofenacum|Diclophenac|Diclofenaco|ProSorb-D|2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid|Diclofenac resinate|Voltarol|Diclofenac free acid|2-(2,6-Dichloroanilino)phenylacetic Acid|Zorovolex|Zorvol

规格或纯度：>98.0%

英文名称：Diclofenac

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target COX Diclofenac is a nonsteroidal anti-inflammatory drμg (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thoμght to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.Diclofenac (双氯芬酸) 是COX抑制剂，对绵羊的COX-1和-2的IC50分别为60和220 nM。Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target COX Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.Diclofenac acid is a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor.

IUPAC Name：2-[2-(2,6-dichloroanilino)phenyl]acetic acid

INCHI：InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)

InChi Key：DCOPUUMXTXDBNB-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

Isomeric SMILES：C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

RTECS：AG6310000

PubChem CID：3033

Reaxy-Rn：2146636

DrugBank Ligand：DB00586

CAS Registry No.：15307-86-5

ChEBI：CHEBI47381

ChEMBL Ligand：CHEMBL139

BindingDB Ligand：13066

Wikipedia：Diclofenac

BitterDB Ligand：942

RCSB PDB Ligand：DIF

PEP：diclofenac

DrugCentral Ligand：865

溶解性：Chloroform (Slightly, Heated), Methanol (Slightly)

熔点：158°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH411 Toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P264,P260,P201,P308+P313,P270,P391,P202,P301+P310+P330

Merck Index：3081

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