产品名称

英文名称：Rifaximin

同义词

Rifaximin、Rifaxidin、Rifacol、Rifamycin L 105、80621-81-4、Xifaxan、Fatroximin、Rifaximine、Normix、Rifamycin L 105SV、Rifaximina、Rifamixin、Ritacol、Rifaximinum、Xifaxsan、Rifaximinum [Latin]、Rifaxin、rifaximinun、L-105、L 105SV、L 105 (Ansamacrolide antibiotic)、Rifaximi、利福昔明、利福昔明、利福西亚胺

产品性质

CAS编号：80621-81-4

分子式：C43H51N3O11

分子量：785.88

MDL号：MFCD00864973

PubChem编号：6436173

别名：利福昔明|利福昔明|利福西亚胺

英文别名：Rifaximin|Rifaxidin|Rifacol|Rifamycin L 105|80621-81-4|Xifaxan|Fatroximin|Rifaximine|Normix|Rifamycin L 105SV|Rifaximina|Rifamixin|Ritacol|Rifaximinum|Xifaxsan|Rifaximinum [Latin]|Rifaxin|rifaximinun|L-105|L 105SV|L 105 (Ansamacrolide antibiotic)|Rifaximi

规格或纯度：≥97%

英文名称：Rifaximin

生化机理：Rifaximin is an antibiotic that inhibits RNA synthesis and acts as a PXR (pregnane-X-receptor) activator. The compound is a derivative of rifamycin that has been shown to act strongly against Enterococcus, Streptococcus and Staphylococcus, with less activity against Enterobacteriaceae. Rifaximin has been used in a variety of gastrointestinal and intestinal epithelial cell studies.Broad spectrum antibiotic against gram-positive and gram-negative bacteria. Inhibits bacterial RNA synthesis. Pregnane X receptor activator. Rifamycin analog. Orally active. Anti-infective and antibacterial agent. Active in vitro and in vivo .

应用：An antibiotic that inhibits RNA synthesis and activates PXR.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍Rifaximin是一种胃肠道选择性的抗生素 (antibiotic)，与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合，从而抑制细菌 RNA 的合成 (bacterial RNA synthesis)。与革兰氏阴性菌（MIC8-50 毫克/毫升）相比，Rifaximin对革兰氏阳性菌株（MIC0.03-5 毫克/毫升）的敏感性更高。Rifaximin 是Rifamycin SV衍生的一种半合成的，非全身性抗生素，具有抗菌活性。Rifaximin, an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity.An antibiotic that inhibits RNA synthesis and activates PXR.

ALogP：6.9

IUPAC Name：[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] acetate

INCHI：InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1

InChi Key：NZCRJKRKKOLAOJ-XRCRFVBUSA-N

Canonical SMILES：CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C

Isomeric SMILES：C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)/C

PubChem CID：6436173

CAS Registry No.：80621-81-4

ChEMBL Ligand：CHEMBL1617

Wikipedia：Rifaximin

ChEBI：CHEBI75246

DrugBank Ligand：DB01220

RCSB PDB Ligand：RXM

Antibiotic DB：1859

溶解性：Soluble in DMSO (47 mg/ml), water (<1 mg/ml), ethanol (157 mg/ml), alcohols, and chloroform.

敏感性：对热敏感

熔点：212 °C

象形图：

信号词：Warning

危险声明：H335 May cause respiratory irritationH312 Harmful in contact with skinH332 Harmful if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P271,P304+P340,P403+P233,P362+P364,P203,P318,P317,P319

Merck Index：8220

产品包装