产品名称

英文名称：Fostamatinib (R788)

同义词

Fostamatinib、901119-35-5、R788、Fostamatinib (R788)、Tavlesse、R788 compound、Tavalisse、R-935788 Free acid、Fostamatinib(R788)、R-788 Free acid、R935788 FREE ACID、R788 FREE ACID、R 788、R-788、[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimeth

产品性质

CAS编号：901119-35-5

分子式：C23H26FN6O9P

分子量：580.46

PubChem编号：11671467

英文别名：Fostamatinib|901119-35-5|R788|Fostamatinib (R788)|Tavlesse|R788 compound|Tavalisse|R-935788 Free acid|Fostamatinib(R788)|R-788 Free acid|R935788 FREE ACID|R788 FREE ACID|R 788|R-788|[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimeth

规格或纯度：≥98%

英文名称：Fostamatinib (R788)

生化机理：R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, sμggesting that they are antigen driven.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Fostamatinib (R788)是活性代谢产物R406的前体药物，是一种Syk抑制剂，IC50为41 nM，强效抑制Syk但不抑制Lyn，对Flt3作用效果低5倍。Phase 3。An inhibitor to spleenic kinase-mediated IgG Fc receptor signalingFostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling

ALogP：1.6

IUPAC Name：[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

INCHI：InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)

InChi Key：GKDRMWXFWHEQQT-UHFFFAOYSA-N

Canonical SMILES：CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

Isomeric SMILES：CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

PubChem CID：11671467

Wikipedia：Fostamatinib

ChEMBL Ligand：CHEMBL2103830

CAS Registry No.：901119-35-5

RCSB PDB Ligand：2RC

DrugCentral Ligand：5280

溶解性：DMSO 116 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装