![]()
产品详情
产品名称 英文名称:Fostamatinib (R788) 同义词 Fostamatinib、901119-35-5、R788、Fostamatinib (R788)、Tavlesse、R788 compound、Tavalisse、R-935788 Free acid、Fostamatinib(R788)、R-788 Free acid、R935788 FREE ACID、R788 FREE ACID、R 788、R-788、[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimeth 产品性质 CAS编号:901119-35-5 分子式:C23H26FN6O9P 分子量:580.46 PubChem编号:11671467 英文别名:Fostamatinib|901119-35-5|R788|Fostamatinib (R788)|Tavlesse|R788 compound|Tavalisse|R-935788 Free acid|Fostamatinib(R788)|R-788 Free acid|R935788 FREE ACID|R788 FREE ACID|R 788|R-788|[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimeth 规格或纯度:≥98% 英文名称:Fostamatinib (R788) 生化机理:R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, sμggesting that they are antigen driven. 储存温度:-20°C储存 运输条件:超低温冰袋运输 产品介绍:Fostamatinib (R788)是活性代谢产物R406的前体药物,是一种Syk抑制剂,IC50为41 nM,强效抑制Syk但不抑制Lyn,对Flt3作用效果低5倍。Phase 3。An inhibitor to spleenic kinase-mediated IgG Fc receptor signalingFostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling ALogP:1.6 IUPAC Name:[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate INCHI:InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29) InChi Key:GKDRMWXFWHEQQT-UHFFFAOYSA-N Canonical SMILES:CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C Isomeric SMILES:CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C PubChem CID:11671467 Wikipedia:Fostamatinib ChEMBL Ligand:CHEMBL2103830 CAS Registry No.:901119-35-5 RCSB PDB Ligand:2RC DrugCentral Ligand:5280 溶解性:DMSO 116 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 象形图: 信号词:Warning 危险声明:H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation 预防措施声明:P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319 产品包装
免责声明:以上所展示的信息由企业自行提供,内容的真实性
、准确性和合法性由发布企业负责,chemdig对此不承担任何保证责任。 同时我们郑重提醒各位买/卖家,
交易前 请详细核实对方身份,切勿随意打款或发货,谨防上当受骗。如发现虚假信息,请向chemdig举报。 |
上海阿拉丁生化科技股份有限公司
|
上海阿拉丁生化科技股份有限公司
邮箱 | market@aladdin-e.com |
联系人 | 18521732826 |
咨询请告知是在ChemDig上看到的,有助于交易达成。