产品名称

英文名称：WZ4002

同义词

WZ4002、1213269-23-8、WZ-4002、N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide、WZ 4002、CHEBI61400、N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide

产品性质

CAS编号：1213269-23-8

分子式：C25H27ClN6O3

分子量：494.97

PubChem编号：44607530

英文别名：WZ4002|1213269-23-8|WZ-4002|N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide|WZ 4002|CHEBI61400|N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide

规格或纯度：≥98%

英文名称：WZ4002

生化机理：WZ 4002 is an inhibitor of EGFR phosphorylation in a variety of cancer cell lines including NIH-3T3 and H1975 cells. WZ 4002 is a potent inhibitor of EGFR, exhibiting an IC50 = 2 nM. This induces apoptosis in the cell due to the blocking of signal transduction from EGFR.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg、10mg卖完停产，不再备货

产品介绍：WZ4002是一种新型的，突变选择性的EGFR抑制剂，作用于EGFR(L858R)/(T790M)时IC50为2 nM/8 nM；对ERBB2磷酸化(T798I)没有抑制作用。An EGFR phosphorylation inhibitorWZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I).An EGFR phosphorylation inhibitor

IUPAC Name：N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

INCHI：InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)

InChi Key：ITTRLTNMFYIYPA-UHFFFAOYSA-N

Canonical SMILES：CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC

Isomeric SMILES：CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC

PubChem CID：44607530

CAS Registry No.：1213269-23-8

ChEMBL Ligand：CHEMBL1229592

BindingDB Ligand：50383274

RCSB PDB Ligand：0UN

Reactome Reaction：R-HSA-1220611, R-HSA-1225978

Reactome Drug：R-ALL-1227674

溶解性：Soluble in DMSO (13 mg/ml) at 25 °C, water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C

产品包装