产品名称

英文名称：VX-222 (VCH-222, Lomibuvir)

同义词

Lomibuvir、VX-222、1026785-59-0、1026785-55-6、VCH-222、VX-222 (VCH-222, Lomibuvir)、cis-Lomibuvir、Lomibuvir (VX-222)、37L2LF4A2D、5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid、1026785-55-6 (or

产品性质

CAS编号：1026785-59-0

分子式：C25H35NO4S

分子量：445.63

PubChem编号：24798764

英文别名：Lomibuvir|VX-222|1026785-59-0|1026785-55-6|VCH-222|VX-222 (VCH-222, Lomibuvir)|cis-Lomibuvir|Lomibuvir (VX-222)|37L2LF4A2D|5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid|1026785-55-6 (or

规格或纯度：≥99%

英文名称：VX-222 (VCH-222, Lomibuvir)

生化机理：VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Lomibuvir (VX-222, VCH-222)是一种新型的，有效的，选择性的HCV聚合酶抑制剂，IC50为0.94-1.2 μM，作用于突变型M423T效果低15.3倍，作用于突变型I482L效果低108倍。Phase 2。ApplicationsIn HCV replicon cells, VX-222 dose-dependently increases IFN-β promoter activity by 5.0-fold and inhibits HCV activity with EC50 and EC90 values of 0.3 and 12 nM, respectively. Also, VX-222 rescues the Sendai virus-activated Rig-I pathway due to the inhibition of viral replication.

IUPAC Name：5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid

INCHI：InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)

InChi Key：WPMJNLCLKAKMLA-UHFFFAOYSA-N

Canonical SMILES：CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O

Isomeric SMILES：CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O

关联CAS：1026785-55-6

PubChem CID：24798764

溶解性：DMSO 89 mg/mL Water <1 mg/mL Ethanol 89 mg/mL

产品包装