产品名称

英文名称：Daclatasvir (BMS-790052)

同义词

NCGC00346533-09、SCHEMBL17897804、1214735-16-6、BDBM50387084、GTPL11266、SMR004702917、Carbamic acid, N,N'-((1,1'-biphenyl)-4,4'-diylbis(1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl((1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl)))bis-, C,C'-dimethyl ester、CS-64、达卡他韦

产品性质

CAS编号：1009119-64-5

分子式：C40H50N8O6

分子量：738.89

PubChem编号：25154714

别名：达卡他韦

英文别名：NCGC00346533-09|SCHEMBL17897804|1214735-16-6|BDBM50387084|GTPL11266|SMR004702917|Carbamic acid, N,N'-((1,1'-biphenyl)-4,4'-diylbis(1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl((1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl)))bis-, C,C'-dimethyl ester|CS-64

规格或纯度：≥98%

英文名称：Daclatasvir (BMS-790052)

生化机理：Daclatasvir (BMS-790052; EBP 883) is a first-in-class, highly-selective oral HCV NS5A inhibitor. NS5A is an essential component for hepatitis C virus (HCV) replication complex.Daclatasvir (BMS-790052; EBP 883)has broad genotype coverage and exhibits picomolar in vitro potency against genotypes 1a (EC50 50pm) and 1b (EC50 9pm).Daclatasvir (BMS-790052; EBP 883) produces a robust decline in HCV RNA (-3.6 logs after 48 hours from a single 100 mg) dosefollowing a single dose in patients chronically infected with HCV genotype 1.Daclatasvir a potent, direct acting, small\xa0 molecule inhbitor of HCV NS5A protein. It inhbibits replicons expressing a wide range of HCV genotypes with EC 50 values in the pM range (9 and 71 pM against the 1b and 2a genotypes, respectively). It also in

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Daclatasvir (BMS-790052)是一种高度选择性的HCV NS5A抑制剂，EC50为9-50 pM，在细胞培养中，作用于多种HCV复制基因型和JFH-1基因型2a的感染性病毒。Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture.

PubChem SID：488200771

IUPAC Name：methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

INCHI：InChI=1S/C40H50N8O6/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6/h11-18,21-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52)/t31-,32-,33-,34-/m0/s1

InChi Key：FKRSSPOQAMALKA-CUPIEXAXSA-N

Canonical SMILES：CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC

Isomeric SMILES：CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC

PubChem CID：25154714

CAS Registry No.：1009119-64-5

ChEMBL Ligand：CHEMBL2023898

BindingDB Ligand：50387084

DrugBank Ligand：DB09102

DrugCentral Ligand：4875

溶解性：DMSO 148 mg/mL Water <1 mg/mL Ethanol 148 mg/mL

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH317 May cause an allergic skin reaction

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P260,P271,P304+P340,P403+P233,P272,P333+P313,P362+P364,P264+P265,P337+P317,P319

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