产品名称

英文名称：PHA-793887

同义词

PHA-793887、718630-59-2、3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide、N-(6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide

产品性质

CAS编号：718630-59-2

分子式：C19H31N5O2

分子量：361.48

PubChem编号：46191454

英文别名：PHA-793887|718630-59-2|3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide|N-(6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide

规格或纯度：≥95%

英文名称：PHA-793887

生化机理：PHA-793887 is a novel pan-Cdk inhibitor, including Cdk1, Cdk2, Cdk4, Cdk5, Cdk7, and Cdk9 with IC50’s in the 5 to 140 nM range. PHA-793887 is inactive against 34 other kinases representative of all kinase families, in particular c-abl, c-kit, lck, and TRKA with IC50>10 mM. PHA-793887 shows anti-proliferative activity against several solid tumor cell lines, with IC50<1 mM; in these cells, it is able to inhibit Rb phosphorylation and expression of S-phase cyclins, such as cyclin A.

应用：a novel pan-Cdk inhibitor inactive against 34 other kinases.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、50mg卖完停产，不再备货

产品介绍：PHA-793887是一种新型有效的CDK2，CDK5和CDK7抑制剂，IC50分别为8 nM， 5 nM 和10 nM，作用于CDK2， 5，和7比作用于CDK1， 4，和9选择性高6倍以上。a novel pan-Cdk inhibitor inactive against 34 other kinases.PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9.a novel pan-Cdk inhibitor inactive against 34 other kinases.

ALogP：1

IUPAC Name：N-[6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide

INCHI：InChI=1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25)

InChi Key：HUXYBQXJVXOMKX-UHFFFAOYSA-N

Canonical SMILES：CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C

Isomeric SMILES：CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C

PubChem CID：46191454

溶解性：DMSO ≥70mg/mL Water <1.2mg/mL Ethanol ≥70mg/mL

产品包装