产品名称

英文名称：SB743921

同义词

940929-33-9、SB 743921、SB743921、(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride、SB-743921、SB-743921 HCl、SB743921 HCl、2YW6FB68GM、SB-743921 hydrochloride、UNII-2YW6FB68GM、Benzamide, N-(3-ami

产品性质

CAS编号：940929-33-9

分子式：C31H34Cl2N2O3

分子量：553.53

PubChem编号：49867937

英文别名：940929-33-9|SB 743921|SB743921|(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride|SB-743921|SB-743921 HCl|SB743921 HCl|2YW6FB68GM|SB-743921 hydrochloride|UNII-2YW6FB68GM|Benzamide, N-(3-ami

规格或纯度：≥95%

英文名称：SB743921

生化机理：SB-743921 is greater efficacy in vivo against P388 leukemia. SB-743921 has significant efficacy in a broad spectrum of tumor models differing from that of taxanes. SB-743921 is shown to have activity against advanced human tumor xenografts Colo205 (complete regressions), MCF-7, SK-MES, H69, OVCAR-3 (complete and partial regressions), and HT-29, MX-1, MDA-MB-231, A2780 (tumor growth delay). SB-743921 doesn't cause the neuropathy often associated with the tubulin agents.Potent kinesin spindle protein KIF11 inhibitor (K i = 0.1 nM). Induces mitotic arrest and apoptosis. Suppresses ERK and AKT activity. Shows antiproliferative effects. Shows antitumor effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：SB-743921是第二代高活性KSP抑制剂，Ki为0.1 nM，对MKLP1，Kin2，Kif1A，Kif15，KHC，Kif4和CENP-E无亲和力。SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.

IUPAC Name：N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide;hydrochloride

INCHI：InChI=1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1

InChi Key：MLMZVWABFOLFGV-LNLSOMNWSA-N

Canonical SMILES：CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

Isomeric SMILES：CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

WGK Germany：3

PubChem CID：49867937

溶解性：DMSO 111 mg/mL Water 22 mg/mL Ethanol 111 mg/mL

产品包装