产品名称

英文名称：4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride

同义词

136647-02-4、UK 78282 HYDROCHLORIDE、4-((Benzhydryloxy)methyl)-1-(3-(4-methoxyphenyl)propyl)piperidine hydrochloride、UK-78282 HCl、UK-78282 Hydrochloride、4-((Benzhydryloxy)methyl)-1-(3-(4-methoxyphenyl)-propyl)piperidine hydrochloride、4-[(DIPHENYLMETHOXY)MET

产品性质

CAS编号：136647-02-4

分子式：C29H35NO2HCl

分子量：466.05

MDL号：MFCD16875438

PubChem编号：53393337

英文别名：136647-02-4|UK 78282 HYDROCHLORIDE|4-((Benzhydryloxy)methyl)-1-(3-(4-methoxyphenyl)propyl)piperidine hydrochloride|UK-78282 HCl|UK-78282 Hydrochloride|4-((Benzhydryloxy)methyl)-1-(3-(4-methoxyphenyl)-propyl)piperidine hydrochloride|4-[(DIPHENYLMETHOXY)MET

规格或纯度：≥98% (HPLC)

英文名称：4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride

生化机理：T淋巴细胞中KV1.3和KV1.4电压门控钾通道的阻滞剂（IC50值分别为0.28和0.17μM）。抑制T淋巴细胞的有丝分裂；导致膜去极化。还阻止在心脏和大脑中表达的KV1.4。UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine;hydrochloride

INCHI：InChI=1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H

InChi Key：ZZSQARULZYQMIG-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=C(C=C1)CCCN2CCC(CC2)COC(C3=CC=CC=C3)C4=CC=CC=C4.Cl

Isomeric SMILES：COC1=CC=C(C=C1)CCCN2CCC(CC2)COC(C3=CC=CC=C3)C4=CC=CC=C4.Cl

WGK Germany：3

PubChem CID：53393337

溶解性：溶于DMSO, 最高浓度 (mg/mL) 23.3, 最高浓度(mM) 50；溶于ethanol, 最高浓度 (mg/mL) 13.98, 最高浓度(mM) 30

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH400 Very toxic to aquatic life

预防措施声明：P305+P351+P338,P273,P280,P501,P391,P264+P265,P337+P317

产品包装