产品名称

英文名称：SNX-2112 (PF-04928473)

同义词

SNX-2112、908112-43-6、4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide、PF-04928473、SNX2112、SNX 2112、10C9P3FFOW、CHEMBL560895、CHEMBL561224、4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,

产品性质

CAS编号：908112-43-6

分子式：C23H27F3N4O3

分子量：464.48

PubChem编号：24772860

英文别名：SNX-2112|908112-43-6|4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide|PF-04928473|SNX2112|SNX 2112|10C9P3FFOW|CHEMBL560895|CHEMBL561224|4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,

规格或纯度：≥98%

英文名称：SNX-2112 (PF-04928473)

生化机理：SNX-2112 is a potent synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 μM for K562 cells.Potent selective Hsp90 inhibitor.\xa0Binds to the ATP pocket of\xa0Hsp90 alpha\xa0and\xa0Hsp90 beta.\xa0Studies demonstates that SNX-2112 can exhibit a potent anticancer activity against B16 melanoma cells both in vitro and in vivo, by inhibiting cell pro

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍SNX-2112 (PF-04928473)选择性结合到HSP90α和HSP90β的ATP结合袋中，Ka分别为30 nM和30 nM，比17-AAG更有效。

IUPAC Name：4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide

INCHI：InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)

InChi Key：ZFVRYNYOPQZKDG-UHFFFAOYSA-N

Canonical SMILES：CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C

Isomeric SMILES：CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C

PubChem CID：24772860

溶解性：DMSO 93 mg/mL Water <1 mg/mL Ethanol 1 mg/mL

产品包装