产品名称

英文名称：Torin 1

同义词

Torin 1、1222998-36-8、Torin-1、Torin1、1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one、1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-

产品性质

CAS编号：1222998-36-8

分子式：C35H28F3N5O2

分子量：607.62

PubChem编号：49836027

英文别名：Torin 1|1222998-36-8|Torin-1|Torin1|1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one|1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-

规格或纯度：≥97%

英文名称：Torin 1

生化机理：Torin 1 is potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.Potent, selective, ATP-competitive\xa0mTOR inhibitor that directly inhibits both mTORC1 and mTORC2 complexes, with IC 50 values between 2 and 10 nM in in vitro kinase assays. Displays 1000-fold selectivity for mTOR over PI3K, 200-fold selectivity for mTOR

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Product DescriptionTorin 1 is an effective inhibitor of mTORC1/2 with (IC50 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.

IUPAC Name：1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one

INCHI：InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3

InChi Key：AKCRNFFTGXBONI-UHFFFAOYSA-N

Canonical SMILES：CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F

Isomeric SMILES：CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F

PubChem CID：49836027

ChEMBL Ligand：CHEMBL1256459

CAS Registry No.：1222998-36-8

溶解性：DMSO 2 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对光敏感

产品包装