产品名称

英文名称：VE-821

同义词

VE-821、1232410-49-9、3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide、VE 821、VE821、3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide、CHEMBL1766779、3-amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide、BF884T

产品性质

CAS编号：1232410-49-9

分子式：C18H16N4O3S

分子量：368.41

PubChem编号：51000408

英文别名：VE-821|1232410-49-9|3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide|VE 821|VE821|3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide|CHEMBL1766779|3-amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide|BF884T

规格或纯度：≥98%

英文名称：VE-821

生化机理：VE-821 is a novel ATR inhibitor. VE-821, sensitises tumour cells to DNA damage induced by radiation or chemotoxic drμgs, by disrupting the DNA damage checkpoint and inhibiting DNA repair.Potent, selective ATP competitive ATR inhibitor (K i\xa0= 13 nM). Exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro . Decreases phosphorylation of Chk1 and increases sensitivity of pancreatic cancer cells

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：VE-821是ATP竞争性，高活性ATR选择性抑制剂，Ki和IC50分别为13 nM和26 nM，与ATM，DNA-PK和mTOR等的交叉反应极低。VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.

IUPAC Name：3-amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide

INCHI：InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23)

InChi Key：DUIHHZKTCSNTGM-UHFFFAOYSA-N

Canonical SMILES：CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N

Isomeric SMILES：CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N

PubChem CID：51000408

CAS Registry No.：1232410-49-9

ChEMBL Ligand：CHEMBL1766779

溶解性：DMSO 74 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装