产品名称

英文名称：A-674563

同义词

A-674563、552325-73-2、A674563、A 674563、(2s)-1-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-Phenylpropan-2-Amine、3W2X0WGW6C、(S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine、(S)-1-((5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)

产品性质

CAS编号：552325-73-2

分子式：C22H22N4O

分子量：358.44

PubChem编号：11314340

英文别名：A-674563|552325-73-2|A674563|A 674563|(2s)-1-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-Phenylpropan-2-Amine|3W2X0WGW6C|(S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine|(S)-1-((5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)

规格或纯度：≥98%

英文名称：A-674563

生化机理：A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 μM. A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells.

应用：A selective Akt1, PKA, and CDK2 inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：A-674563是Akt1抑制剂，IC50为14 nM，还能抑制PKA和CDK2，IC50分别为16和46 nM。A selective Akt1, PKA, and CDK2 inhibitorA-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.A selective Akt1, PKA, and CDK2 inhibitor

IUPAC Name：(2S)-1-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy-3-phenylpropan-2-amine

INCHI：InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1

InChi Key：BPNUQXPIQBZCMR-IBGZPJMESA-N

Canonical SMILES：CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OCC(CC4=CC=CC=C4)N

Isomeric SMILES：CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CC=CC=C4)N

PubChem CID：11314340

CAS Registry No.：552325-73-2

DiscoveRx TREEspot：A-674563|

ChEMBL Ligand：CHEMBL379218

RCSB PDB Ligand：SS3

溶解性：DMSO 72 mg/mL Water 72 mg/mL Ethanol 18 mg/mL

密度：1.2

折光率：1.66

沸点：~624.4° C at 760 mmHg

熔点：243.14°C

产品包装