产品名称

英文名称：PF-04929113 (SNX-5422)

同义词

SNX-5422、908115-27-5、PF-04929113、PF-4929113、SNX 5422、PF-04929113 (SNX-5422)、PF-04929113 free base、PF 04929113、BF52J69Q8T、PF04929113、SNX5422、908115-27-5 (free base)、(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-ind、甘氨酸反式-4-[[2-(氨基羰基)-5-[4,5,6,7-四氢-6,6-二甲基-4-氧代-3-(三氟甲基)-1H-吲唑-1-基]苯基]氨基]环己酯

产品性质

CAS编号：908115-27-5

分子式：C25H30F3N5O4

分子量：521.54

PubChem编号：44195571

别名：甘氨酸反式-4-[[2-(氨基羰基)-5-[4,5,6,7-四氢-6,6-二甲基-4-氧代-3-(三氟甲基)-1H-吲唑-1-基]苯基]氨基]环己酯

英文别名：SNX-5422|908115-27-5|PF-04929113|PF-4929113|SNX 5422|PF-04929113 (SNX-5422)|PF-04929113 free base|PF 04929113|BF52J69Q8T|PF04929113|SNX5422|908115-27-5 (free base)|(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-ind

规格或纯度：≥98%

英文名称：PF-04929113 (SNX-5422)

生化机理：PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). PF-04929113 is a small-molecule Hsp90 inhibitor based on the 6,7-dihydro-indazol-4-one scaffold. PF-04929113 exhibits potent effects on Her-2 stability and causes expected up-regulation of Hsp70. PF-04929113 shows potent antiproliferative activity against a broad range of cancer cell types, e.g. MCF-7 (IC50=16 nM), SW620 (IC50 of 19 nM), K562 (IC50 of 23 nM), SK-MEL-5 (IC50 of 25 nM), and A375 (IC50 of 51 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有毒，请参考SDS，以获取更多信息。需要更多有关溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PF-04929113 (SNX-5422)是一种有效的，选择性的HSP90抑制剂，Kd为41 nM，且诱导Her-2降解，IC50为37 nM。Phase 1/2。PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.

ALogP：3.5

IUPAC Name：[4-[2-carbamoyl-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]anilino]cyclohexyl] 2-aminoacetate

INCHI：InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)

InChi Key：AVDSOVJPJZVBTC-UHFFFAOYSA-N

Canonical SMILES：CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C

Isomeric SMILES：CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C

PubChem CID：44195571

溶解性：DMSO 104 mg/mL Water <1 mg/mL Ethanol 5 mg/mL

产品包装