产品名称

英文名称：Pitolisant

同义词

Pitolisant、362665-56-3、TIPROLISANT、wakix、1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine、BF2.649、HBS-101、1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine、UNII-4BC83L4PIY、4BC83L4PIY、1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine、Piperidine, 1-[3-[3-(

产品性质

CAS编号：362665-56-3

分子式：C17H26ClNO

分子量：295.85

PubChem编号：9948102

英文别名：Pitolisant|362665-56-3|TIPROLISANT|wakix|1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine|BF2.649|HBS-101|1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine|UNII-4BC83L4PIY|4BC83L4PIY|1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine|Piperidine, 1-[3-[3-(

规格或纯度：≥98%

英文名称：Pitolisant

生化机理：DescriptionIC50 Value 0.16 nM(Ki value); 1.5 nM(EC50) [1]Pitolisant (BF2.649) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor. BF2.649 behaved as a competitive antagonist with a Ki value of 0.16 nM and as an inverse agonist with an EC50 value of 1.5 nM and an intrinsic activity approximately 50% higher than that of ciproxifan.in vitro BF2.649 behaved as a competitive antagonist with a Ki value of 0.16 nM and as an inverse agonist with an EC50 value of 1.5 nM and an intrinsic activity approximately 50% higher than that of ciproxifan. Pitolisant in vitro potency was approximately 6 times lower at the rodent receptor [1].in vivo In mice, the oral bioavailability coefficient, i.e., the ratio of plasma areas under the curve after oral and i.v. administrations, respectively, was 84%. BF2.649 dose dependently enhanced tele-methylhistamine levels in mouse brain, an index of histaminergic neur

运输条件：常规运输

备注：卖完停产，不再备货

产品介绍：Pitolisant(BF2.649;Ciproxidine)是新型的人重组H3受体选择性反向激动剂，Ki为0.16 nM。Pitolisant (BF2.649) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).

ALogP：4.3

IUPAC Name：1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine

INCHI：InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2

InChi Key：NNACHAUCXXVJSP-UHFFFAOYSA-N

Canonical SMILES：C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl

Isomeric SMILES：C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl

PubChem CID：9948102

ChEMBL Ligand：CHEMBL462605

CAS Registry No.：362665-56-3

Wikipedia：Pitolisant

DrugCentral Ligand：5048

GPCRdb Ligand：pitolisant

溶解性：DMSO

产品包装