产品名称

英文名称：PF-8380

同义词

PF-8380、1144035-53-9、3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate、PF8380、(3,5-Dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate、PF 8380、T582DIM5A4

产品性质

CAS编号：1144035-53-9

分子式：C22H21Cl2N3O5

分子量：478.33

PubChem编号：25265312

英文别名：PF-8380|1144035-53-9|3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate|PF8380|(3,5-Dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate|PF 8380|T582DIM5A4

规格或纯度：≥98%

英文名称：PF-8380

生化机理：PF-8380 is an orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PF-8380是高活性的autotaxin特异性抑制剂，IC50为2.8 nM。A substrate competitive and tight-binding inhibitor of autotaxin.PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM.A substrate competitive and tight-binding inhibitor of autotaxin.

IUPAC Name：(3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate

INCHI：InChI=1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29)

InChi Key：JMSUDQYHPSNBSN-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl

Isomeric SMILES：C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl

WGK Germany：3

PubChem CID：25265312

CAS Registry No.：1144035-53-9

ChEMBL Ligand：CHEMBL3186509

RCSB PDB Ligand：6ZO

溶解性：Soluble in DMSO (100 mM), water (slightly), DMF (~5 mg/ml), and DMFPBS (pH 7.2)(16) (~0.14 mg/ml).

产品包装