产品名称

英文名称：BGJ398 (NVP-BGJ398)

同义词

Infigratinib、NVP-BGJ398、872511-34-7、BGJ398、BGJ-398、BGJ 398、3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea、Infigratinib [INN]、Infigratinib free base、UNII-A4055ME1VK、A4055ME1VK、Infigratinib [US

产品性质

CAS编号：872511-34-7

分子式：C26H31Cl2N7O3

分子量：560.48

PubChem编号：53235510

英文别名：Infigratinib|NVP-BGJ398|872511-34-7|BGJ398|BGJ-398|BGJ 398|3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea|Infigratinib [INN]|Infigratinib free base|UNII-A4055ME1VK|A4055ME1VK|Infigratinib [US

规格或纯度：≥98%

英文名称：BGJ398 (NVP-BGJ398)

生化机理：BGJ398 is a potent and selective fibroblast growth factor receptor family inhibitor for Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、25mg卖完停产，不再备货

产品介绍：BGJ398 (NVP-BGJ398)是一种有效的，选择性的FGFR抑制剂，作用于FGFR1/2/3，IC50为0.9 nM/1.4 nM/1 nM，作用于FGFR比作用于FGFR4和VEGFR2选择性高40倍以上，对Abl， Fyn， Kit， Lck， Lyn和Yes几乎没有抑制活性。Phase 2。A potent and selective inhibitor of Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4.BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.A potent and selective inhibitor of Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4.

ALogP：4.7

IUPAC Name：3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea

INCHI：InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)

InChi Key：QADPYRIHXKWUSV-UHFFFAOYSA-N

Canonical SMILES：CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl

Isomeric SMILES：CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl

PubChem CID：53235510

CAS Registry No.：872511-34-7

ChEMBL Ligand：CHEMBL1852688

RCSB PDB Ligand：07J

Reactome Reaction：R-HSA-2077420, R-HSA-2077424, R-HSA-2023462, R-HSA-2029992

Reactome Drug：R-ALL-2038925

DrugCentral Ligand：5459

溶解性：DMSO 1 mg/mL heating (1 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM)

产品包装