产品名称

英文名称：BGT226 (NVP-BGT226) maleate

同义词

NVP-BGT226、1245537-68-1、BGT226、BGT-226 maleate、BGT226 maleate、BGT-226、BGT226 (NVP-BGT226)、UNII-4YG62LG876、BGT226 (maleate)、4YG62LG876、NVP-BGT-226、CHEBI71953、(Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl

产品性质

CAS编号：1245537-68-1

分子式：C28H25F3N6O2.C4H4O4

分子量：650.6

PubChem编号：57336745

英文别名：NVP-BGT226|1245537-68-1|BGT226|BGT-226 maleate|BGT226 maleate|BGT-226|BGT226 (NVP-BGT226)|UNII-4YG62LG876|BGT226 (maleate)|4YG62LG876|NVP-BGT-226|CHEBI71953|(Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl

规格或纯度：≥98%

英文名称：BGT226 (NVP-BGT226) maleate

生化机理：NVP-BGT226 suppresses the activation of the AKT/FRAP(mTOR) signal cascade. NVP-BGT226 potently inhibits growth activity of certain cell lines including SCC4, TU183 and KB cell lines with the IC50 ranging from 7.4 to 30.1 nM. NVP-BGT226 induces cancer cell death throμgh an apoptosis-independent pathway. NVP-BGT226 inhibits growth in common myeloma cell lines and primary myeloma cells (such as NCI-H929, U266, RPMI-8226 and OPM2 MM cell lines) at nanomolar concentrations. NVP-BGT226 inhibits phosphorylation of protein kinase B (Akt), P70S6k, and 4E-BP-1. NVP-BGT226 abates the stimulatory effect of insulin-like growth factor 1, interleukin-6, and conditioned medium of HS-5 stromal cells on myeloma cell growth.

应用：A novel dual PI3K/FRAP inhibitor

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：NVP-BGT226(BGT 226)是PI3K I型抑制剂，对PI3Kα/β/γ的IC50分别为4 nM/63 nM/38 nM。A novel dual PI3K/FRAP inhibitorBGT226 (NVP-BGT226) is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM.A novel dual PI3K/FRAP inhibitor

PubChem SID：488201818

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488201818

IUPAC Name：(Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one

INCHI：InChI=1S/C28H25F3N6O2.C4H4O4/c1-35-24-16-33-22-6-3-17(18-4-8-25(39-2)34-15-18)13-20(22)26(24)37(27(35)38)19-5-7-23(21(14-19)28(29,30)31)36-11-9-32-10-12-36;5-3(6)1-2-4(7)8/h3-8,13-16,32H,9-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChi Key：YUXMAKUNSXIEKN-BTJKTKAUSA-N

Canonical SMILES：CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=CC(=O)O)C(=O)O

Isomeric SMILES：CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O

PubChem CID：57336745

溶解性：DMSO 30 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对湿度敏感

产品包装