产品名称

英文名称：TH-302

同义词

evofosfamide、TH-302、918633-87-1、TH302、HAP-302、TH 302、n,n'-bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl ester、2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine、Evofosfamide(TH-

产品性质

CAS编号：918633-87-1

分子式：C9H16Br2N5O4P

分子量：449.04

PubChem编号：11984561

英文别名：evofosfamide|TH-302|918633-87-1|TH302|HAP-302|TH 302|n,n'-bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl ester|2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine|Evofosfamide(TH-

规格或纯度：≥98%

英文名称：TH-302

生化机理：TH-302 is a newly developed antineoplastic drμg which represents a potential new class of tumor selective hypoxia-activated prodrμgs (HAPs).

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Evofosfamide (TH-302) 是一种缺氧 (hypoxia) 激活前药，缺氧 (N2) 和常氧 (21% O2) 环境下，IC50 分别为 10 μM 和 1000 μM。Evofosfamide (TH-302) is a hypoxia-activated prodrug with IC50 of 10 μM and 1000 μM in hypoxia (N2) and normoxia (21% O2), respectively.

ALogP：0.6

IUPAC Name：2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine

INCHI：InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19)

InChi Key：UGJWRPJDTDGERK-UHFFFAOYSA-N

Canonical SMILES：CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr

Isomeric SMILES：CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr

PubChem CID：11984561

CAS Registry No.：918633-87-1

ChEMBL Ligand：CHEMBL260046

溶解性：DMSO 94 mg/mL (209.34 mM; Need ultrasonic and warming)

产品包装