产品名称

英文名称：BYL719

同义词

alpelisib、1217486-61-7、BYL-719、BYL719、Piqray、Vijoice、NVP-BYL719、BYL 719、UNII-08W5N2C97Q、Alpelisib (BYL719)、08W5N2C97Q、(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide、Alpelisib [USANINN]、1

产品性质

CAS编号：1217486-61-7

分子式：C19H22F3N5O2S

分子量：441.47

PubChem编号：56649450

英文别名：alpelisib|1217486-61-7|BYL-719|BYL719|Piqray|Vijoice|NVP-BYL719|BYL 719|UNII-08W5N2C97Q|Alpelisib (BYL719)|08W5N2C97Q|(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide|Alpelisib [USANINN]|1

规格或纯度：98%

英文名称：BYL719

生化机理：BYL-719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL-719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Alpelisib (BYL719) 是一种有效的选择性PI3Kα抑制剂，在无细胞试验中IC50为 5 nM，对PI3Kβ/γ/δ具有极弱的作用。

ALogP：3.2

IUPAC Name：(2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide

INCHI：InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1

InChi Key：STUWGJZDJHPWGZ-LBPRGKRZSA-N

Canonical SMILES：CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F

Isomeric SMILES：CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F

PubChem CID：56649450

CAS Registry No.：1217486-61-7

ChEMBL Ligand：CHEMBL2396661

RCSB PDB Ligand：1LT

DrugCentral Ligand：5328

溶解性：DMSO 88 mg/mL Water <1 mg/mL Ethanol 5 mg/mL

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P501,P260,P319

产品包装