产品名称

英文名称：BAY 80-6946 (Copanlisib)

同义词

Copanlisib、1032568-63-0、BAY 80-6946、BAY-80-6946、Aliqopa、BAY80-6946、2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide、WI6V529FZ9、2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidaz

产品性质

CAS编号：1032568-63-0

分子式：C23H28N8O4

分子量：480.52

PubChem编号：135565596

英文别名：Copanlisib|1032568-63-0|BAY 80-6946|BAY-80-6946|Aliqopa|BAY80-6946|2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide|WI6V529FZ9|2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidaz

规格或纯度：98%

英文名称：BAY 80-6946 (Copanlisib)

生化机理：BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：250mg卖完停产，不再备货

产品介绍：Copanlisib (BAY 80-6946)是一个高效的泛I型 PI3K抑制剂，其对PI3Kα/β/γ/δ抑制的IC50分别为0.5, 3.7, 6.4, and 0.7 nM。

ALogP：0.3

IUPAC Name：2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide

INCHI：InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14,25H,2,5-12H2,1H3,(H2,24,26,27)

InChi Key：MWYDSXOGIBMAET-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=CC2=C3NCCN3C(=NC(=O)C4=CN=C(N=C4)N)N=C21)OCCCN5CCOCC5

Isomeric SMILES：COC1=C(C=CC2=C3NCCN3C(=NC(=O)C4=CN=C(N=C4)N)N=C21)OCCCN5CCOCC5

PubChem CID：135565596

CAS Registry No.：1032568-63-0

Wikipedia：Copanlisib

ChEMBL Ligand：CHEMBL3218576

RCSB PDB Ligand：6E2

DrugBank Ligand：DB12483

DrugCentral Ligand：5256

溶解性：DMSO 0.002 mg/mL Water 0.002 mg/mL Ethanol 0.01 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338

产品包装