产品名称

英文名称：AM095

同义词

AM095、1345614-59-6、AM-095 Sodium、AM095 sodium、AM-095、sodium;2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetate、CS-1118、DTXSID70693387、BCP16047、EX-A1954、AKOS030526424、AC-35293、AM095, >=98% (HPLC)、AS-55886、HY-1603

产品性质

CAS编号：1345614-59-6

分子式：C27H23N2NaO5

分子量：478.47

PubChem编号：53303875

英文别名：AM095|1345614-59-6|AM-095 Sodium|AM095 sodium|AM-095|sodium;2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetate|CS-1118|DTXSID70693387|BCP16047|EX-A1954|AKOS030526424|AC-35293|AM095, >=98% (HPLC)|AS-55886|HY-1603

规格或纯度：≥98%

英文名称：AM095

生化机理：AM095 is an LPA? receptor antagonist with good oral exposure and antifibrotic activity in rodent models. In vitro, AM095 inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA? with IC?? values of 0.98 and 0.73 μM, respectively, and exhibited no LPA? agonism. In functional assays, AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA? (IC??= 778 nM) and human A2058 melanoma cells (IC?? = 233 nM). Another study showed that LPA/LPA? pathway inhibition has the potential to be an effective new therapeutic strategy for systemic sclerosis (SSc), and that LPA? is an attractive pharmacologic target in dermal fibrosis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg、100mg卖完停产，不再备货

产品介绍：AM095是LPA1受体拮抗剂，对人和小鼠LPA1的IC50分别为0.98和0.73 μM。AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.

IUPAC Name：sodium;2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetate

INCHI：InChI=1S/C27H24N2O5.Na/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31;/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31);/q;+1/p-1/t18-;/m1./s1

InChi Key：BDKDADFSIDCQGB-GMUIIQOCSA-M

Canonical SMILES：CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)[O-].[Na+]

Isomeric SMILES：CC1=NOC(=C1NC(=O)O[C@H](C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)[O-].[Na+]

PubChem CID：53303875

溶解性：DMSO

产品包装