产品名称

英文名称：Trelagliptin

同义词

2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile、EX-A470、A855303、CCG-268122、2-[[6-[(3~{R})-3-azanylpiperidin-1-yl]-3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]methyl]-4-fluoranyl-benzenecarboni trile、TRELA、曲格列汀

产品性质

CAS编号：865759-25-7

分子式：C18H20FN5O2

分子量：357.38

PubChem编号：15983988

别名：曲格列汀

英文别名：2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile|EX-A470|A855303|CCG-268122|2-[[6-[(3~{R})-3-azanylpiperidin-1-yl]-3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]methyl]-4-fluoranyl-benzenecarboni trile|TRELA

规格或纯度：≥98%

英文名称：Trelagliptin

生化机理：Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Trelagliptin 是高度选择性的长效的DPP-4抑制剂。Trelagliptin is a highly selective, long-acting DPP-4 inhibitor.

IUPAC Name：2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile

INCHI：InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1

InChi Key：IWYJYHUNXVAVAA-OAHLLOKOSA-N

Canonical SMILES：CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N

Isomeric SMILES：CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCC[C@H](C3)N

PubChem CID：15983988

溶解性：DMSO66 mg/mL (184.7 mM)；Ethanol3 mg/mL (8.39 mM),warmed；H2O<1 mg/mL

产品包装