产品名称

英文名称：Dovitinib (TKI-258) Dilactic Acid

同义词

多韦替尼二乳酸

产品性质

CAS编号：852433-84-2

分子式：C21H21FN6O·2C3H6O3

分子量：572.59

PubChem编号：135985126

别名：多韦替尼二乳酸

规格或纯度：98%

英文名称：Dovitinib (TKI-258) Dilactic Acid

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍多韦替尼二乳酸是一种有效的、非特异性的生长因子受体激酶抑制剂，对Flt-3、c-kit、VEGFR、PDGFR和CSF-1R均有抑制作用。产品应用Dovitinib Dilactic Acid 是 Dovitinib 的双乳酸，是一种多靶点 RTK 抑制剂，主要用于 III 类 (FLT3/c-Kit)，IC50 为 1 nM/2 nM，对 IV 类 (FGFR1/ 3) 和 V 类 (VEGFR1-4) RTK，IC50 为 8-13 nM，对 InsR、EGFR、c-Met、EphA2、Tie2、IGFR1 和 HER2 的效力较低。Product DescribtionDovitinib Dilactic acid is a potent, non-specific growth factor receptor kinase inhibitor with effects against FLT-3, c-KIT, VEGFR, PDGFRß and CSF-1R, respectively.Product ApplicationDovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2.

IUPAC Name：4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one;2-hydroxypropanoic acid

INCHI：InChI=1S/C21H21FN6O.2C3H6O3/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;2*1-2(4)3(5)6/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2*2,4H,1H3,(H,5,6)

InChi Key：XXLPVQZYQCGXOV-UHFFFAOYSA-N

Canonical SMILES：CC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N

PubChem CID：135985126

溶解性：DMSO83 mg/mL (145 mM) H2O64 mg/mL (111.8 mM) Ethanol<1 mg/mL

产品包装