产品名称

英文名称：AGI-5198

同义词

AGI-5198、1355326-35-0、IDH-C35、N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide、AGI 5198、N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide、N-cyclohexyl-2-(N-(3-fl

产品性质

CAS编号：1355326-35-0

分子式：C27H31FN4O2

分子量：462.56

PubChem编号：56645356

英文别名：AGI-5198|1355326-35-0|IDH-C35|N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide|AGI 5198|N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide|N-cyclohexyl-2-(N-(3-fl

规格或纯度：≥98%

英文名称：AGI-5198

生化机理：突变体异柠檬酸脱氢酶1（mIDH1; IC50 = 70 nM）的有效和选择性抑制剂。对mIDH1的选择优于野生型IDH1和IDH2。抑制合成代谢物D-2羟基戊二酸的产生。在体外和体内，可减轻含有mIDH1但不含野生型IDH1的神经胶质瘤细胞的生长。还抑制带有mIDH1的纤维肉瘤和软骨肉瘤细胞的生长。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.AGI-5198(IDH C35)是剂量依赖的R132H-IDH1抑制剂AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.AGI-5198(IDH C35) is a novel R132H-IDH1 inhibitor, identified through a high-throughput screen blocked R132H-IDH1 activity in a dose-dependent manner.

IUPAC Name：N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide

INCHI：InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34)

InChi Key：FNYGWXSATBUBER-UHFFFAOYSA-N

Canonical SMILES：CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

Isomeric SMILES：CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

WGK Germany：3

PubChem CID：56645356

ChEMBL Ligand：CHEMBL2180727

CAS Registry No.：1355326-35-0

溶解性：溶于DMSO, 最高浓度 (mg/mL) 23.13, 最高浓度(mM) 50；溶于ethanol, 最高浓度 (mg/mL) 4.63, 最高浓度(mM) 10

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

产品包装