产品名称

英文名称：NSC 319726

同义词

NSC319726、71555-25-4、NSC 319726、N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide、CID 5351307、N-[(E)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide、(E)-N'-(1-(pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide、NSC-319726、MLS00270

产品性质

CAS编号：71555-25-4

分子式：C11H14N4S

分子量：234.32

PubChem编号：5351307

英文别名：NSC319726|71555-25-4|NSC 319726|N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide|CID 5351307|N-[(E)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide|(E)-N'-(1-(pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide|NSC-319726|MLS00270

规格或纯度：≥95%

英文名称：NSC 319726

生化机理：NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells, shows 10- to 100-fold selectivity over the other hotspot p53 mutants. NSC319276 induces p53(R175)-mutant-dependent apoptosis. NSC319726 treatment induces a WT-like conformational change in the p53(R175) mutant protein that restores sequence-specific p53 transcription. The activity of NSC319726 depends on the zinc ion chelating properties of the compound as well as redox changes.p53(R175) mutant reactivator. Inhibits growth of fibroblasts expressing the p53(R175) mutation (IC 50 = 8 nM), shows no inhibition for p53 wild-type cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：NSC319726是突变型p53R175再活化剂，能抑制表达p53R175的成纤维细胞增殖，IC50值为8nM，对野生型p53细胞无抑制作用。NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.

IUPAC Name：N-[(E)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide

INCHI：InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9+

InChi Key：XDHBUMNIQRLHGO-UKTHLTGXSA-N

Canonical SMILES：CC(=NNC(=S)N1CCC1)C2=CC=CC=N2

Isomeric SMILES：C/C(=N\NC(=S)N1CCC1)/C2=CC=CC=N2

PubChem CID：5351307

溶解性：DMSO 19 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装