产品名称

英文名称：Emtricitabine

同义词

Emtricitabine、EMTRICITABINE COMPONENT OF DESCOVY、(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine、524-W-91、EMTRICITABINE [ORANGE BOOK]、MFCD00870151、FTC-((-))、AKOS015853098、MLS003882429、Ftc, dl-、Tox21_112193、XQSPYNMVSIKCOC-NTSWFWBYSA-、恩曲他滨

产品性质

CAS编号：143491-57-0

分子式：C8H10FN3O3S

分子量：247.25

MDL号：MFCD00870151

PubChem编号：60877

别名：恩曲他滨

英文别名：Emtricitabine|EMTRICITABINE COMPONENT OF DESCOVY|(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine|524-W-91|EMTRICITABINE [ORANGE BOOK]|MFCD00870151|FTC-((-))|AKOS015853098|MLS003882429|Ftc, dl-|Tox21_112193|XQSPYNMVSIKCOC-NTSWFWBYSA-

规格或纯度：98%

英文名称：Emtricitabine

生化机理：Emtricitabine is a nucleoside analogue which inhibits the reverse nucleoside transcriptase enzyme. Structurally this antiviral agent is similar to Lamivudine. This agent is effective at targeting HIV and HBV viruses since these viruses replicate in a reverse transcriptase manner. Studies indicate that the structure of Emtricitabine, specifically the unnatural β-L structural configuration produce greater antiviral effects in vitro on HIV and HBV than other antiviral agents. To activate Emtricitabine it needs to undergo multistep intracellular phosphorylation by various cellular kinases. These studies sμggest that Emtricitabine competitively inhibits HIV-1 reverse transcriptase (HIV-1 RT) and can cause termination of DNA chain elongation in the virus via incorporation into the viral genome.Competitive reverse transcriptase inhibitor. Nucleoside analog. Shows antiviral effects against HIV and HBV in vivo (IC 50 values are 7 - 75 nM for HIV-1) . Structurally related to Lamivudine . Orally active. Blood-brain barrier permeable.

应用：A HIV-1 reverse transcriptase (HIV-1 RT) inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25/50mg卖完停产，不再备货。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Emtricitabine 是一种核苷逆转录酶抑制剂，IC50为27.7 μMA HIV-1 reverse transcriptase (HIV-1 RT) inhibitorEmtricitabine is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM.A HIV-1 reverse transcriptase (HIV-1 RT) inhibitor

IUPAC Name：4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one

INCHI：InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1

InChi Key：XQSPYNMVSIKCOC-NTSWFWBYSA-N

Canonical SMILES：C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F

Isomeric SMILES：C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F

PubChem CID：60877

RCSB PDB Ligand：ETV

CAS Registry No.：143491-57-0

ChEMBL Ligand：CHEMBL885

ChEBI：CHEBI31536

Wikipedia：Emtricitabine

PEP：emtricitabine

DrugCentral Ligand：1003

溶解性：Soluble in DMSO (≥ 50 mg/ml), water (≥ 50 mg/ml), and ethanol (≥ 17 mg/ml)., Soluble in DMSO (≥ 50 mg/ml), water (≥ 50 mg/ml), and ethanol (≥ 17 mg/ml).

比旋光度：-140° (C=0.25,MeOH)

熔点：155 °C

Merck Index：3565

产品包装