产品名称

英文名称：2-Methoxyestradiol (2-MeOE2)

同义词

2-MeOE2 、 2-Methoxyestradiol 、 2-ME2 、 NSC-659853 、 2-Methoxy-β-estradiol、2-甲氧基雌二醇 、 2-甲氧基-β-雌二醇

产品性质

CAS编号：362-07-2

分子式：C19H26O3

分子量：302.41

MDL号：MFCD00010489

PubChem编号：66414

别名：2-甲氧基雌二醇 | 2-甲氧基-β-雌二醇

英文别名：2-MeOE2 | 2-Methoxyestradiol | 2-ME2 | NSC-659853 | 2-Methoxy-β-estradiol

规格或纯度：≥98%

英文名称：2-Methoxyestradiol (2-MeOE2)

生化机理：2-methoxyestradiol (2ME2) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.2-Methoxyestradiol is an endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. 2-Methoxyestradiol is formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. 2-Methoxyestradiol is a derivative of an oestrogenic steroidal hormone and has demonstrated potent inhibition of endothelial cell proliferation and migration and inhibition of bFGF and VEGF-induced corneal neovascularization in mice. In MDA-MB-231 cells, 2-Methoxyestradiol inhibits HIF mediated transcriptional activation of target genes without affecting the transcription of HIF-1α itself. 2-Methoxyestradiol has been shown to induce apoptosis throμgh activation of the p53 pathway throμgh either activation of p38 and NF-κ.Potent antioxidant. Inhibits angiogenesis in vivo with direct cytotoxic effects seen in vitro . Interacts with endothelial tubulin dynamics and increases the expression of death receptor 5 in endothelial cells. Induces apoptosis by p53 induction via activ

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：2-Methoxyestradiol (2-MeOE2)使微管解聚，且抑制HIF-1α核积累和HIF转录活性。Phase 2。A disruptor of microtubule function and HIF-1 inhibitor最大吸收波长286(EtOH) nm2-Methoxyestradiol (2-MeOE2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.A disruptor of microtubule function and HIF-1 inhibitor

IUPAC Name：(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

INCHI：InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1

InChi Key：CQOQDQWUFQDJMK-SSTWWWIQSA-N

Canonical SMILES：CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O

Isomeric SMILES：C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O

WGK Germany：3

RTECS：KG7537500

PubChem CID：66414

CAS Registry No.：362-07-2

ChEMBL Ligand：CHEMBL299613

BindingDB Ligand：50060957

DrugBank Ligand：DB02342

RCSB PDB Ligand：ESM, ESM

溶解性：Soluble in DMSO (10 mg/mL), ethanol (10 mg/mL), chloroform, ethanol (1 mg/ml), and 11DMFPBS(pH7.2) (0.5 mg/ml). Insoluble in water.

比旋光度：107° (C=0.5,THF)

熔点：187 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaledH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH350 May cause cancerH301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P361+P364,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317,P316,P319

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

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